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Acanthamoeba keratitis (AK) is a rare but sight-threatening ocular infection. Outbreaks have been associated with contaminated water and contact lens wear. The epidemiology and pathology may be associated with unique genotypes. We determined the Rns genotype for 37 clinical isolates from 23 patients presenting at the University of Miami Bascom Palmer Eye(More)
Collagen cross-linking (CXL) is being offered to a growing number of keratoconic patients worldwide for prevention of disease progression, with an overall success rate that exceeds 90% of the treated eyes.1,2 However, some patients do continue to progress after CXL and may need to undergo keratoplasty. Deep anterior lamellar keratoplasty (DALK) has become(More)
OBJECTIVE To study the epidemiology, clinical observations, and microbiologic characteristics of fungal keratitis at tertiary eye care centers in the United States. DESIGN Retrospective multicenter case series. PARTICIPANTS Fungal keratitis cases presenting to participating tertiary eye care centers. METHODS Charts were reviewed for all fungal(More)
PURPOSE To investigate the expression of toll-like receptors (TLRs) in healthy and active vernal keratoconjunctivitis (VKC) conjunctiva. DESIGN Comparative nonrandomized interventional study. PARTICIPANTS Nine patients with vernal keratoconjunctivitis and 10 healthy subjects. METHODS Normal and VKC conjunctiva were evaluated for TLR-2, TLR-4, and(More)
OBJECTIVE To compare combined intrastromal corneal ring segment implantation with same-day ultraviolet-A/riboflavin corneal collagen cross-linking (ICRS-CXL) versus ICRS implantation alone in patients with corneal ectasia. DESIGN Retrospective comparative study. PARTICIPANTS Sixty-six eyes from 54 patients with corneal ectasia were included in the(More)
PURPOSE Ocular surface (OS) microbiota contributes to infectious and autoimmune diseases of the eye. Comprehensive analysis of microbial diversity at the OS has been impossible because of the limitations of conventional cultivation techniques. This pilot study aimed to explore true diversity of human OS microbiota using DNA sequencing-based detection and(More)
PURPOSE To evaluate the efficacy of intrastromal corneal ring segments implantation followed by same-day photorefractive keratectomy (PRK) and ultraviolet-A/riboflavin collagen cross-linking (CXL) in patients with keratoconus. METHODS Four patients (five eyes) were included in the study. All patients first underwent femtosecond laser-enabled placement of(More)
OBJECTIVE To describe a case of severe and drug-resistant Acanthamoeba keratitis in a contact lens wearer caused by atypical T5 Acanthamoeba genotype (Acanthamoeba lenticulata). METHODS Report of a case, Acanthamoeba DNA amplification and sequencing. RESULTS A 61-year-old patient was referred to our clinic with a 2-week history of keratitis.(More)
OBJECTIVE Fungal keratitis is a serious ocular infection that is considered to be rare among contact lens wearers. The recent Fusarium keratitis outbreak raised questions regarding the background rate of Fusarium-related keratitis and other fungal keratitis in this population. DESIGN Retrospective, multicenter case series. PARTICIPANTS Six hundred(More)