Alexis Thomas

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Dupuytren disease (DD) is a common fibroproliferative disease of unknown etiopathogenesis affecting the palmar aponeurosis, causing reduced hand function and resulting in fixed flexion contractures of the digits. Current gold standard treatment for the management of DD is surgical excision involving removal of the affected palmar fascial tissue. However,(More)
History Felix Platter of Switzerland appears to have been the first to document what later came to be called Dupuytren’s disease (DD) in his case report published in 1614 of a stonemason with digital contractures of his ring and little fingers. Unfortunately, he misattributed the deformity to contracture of the flexor tendons so was superseded by later(More)
Dupuytren's disease (DD) is a benign, fibroproliferative disease of the palmar fascia, with excessive extracellular matrix (ECM) deposition and over-production of cytokines and growth factors, resulting in digital fixed flexion contractures limiting hand function and patient quality of life. Surgical fasciectomy is the gold standard treatment but is(More)
A complex profile of volatile organic compounds ("VOC"s) emanates from human skin, which is altered by changes in the body's metabolic or hormonal state, the external environment, and the bacterial species colonizing the skin surface. The aim of this study was to compare VOC profiles sampled from chronic leg wounds with those from asymptomatic skin. Five(More)
The Florida Department of Transportation has developed a new, more efficient process for conducting environmental reviews of transportation projects. A key component of the process is Florida's Environmental Screening Tool, an interactive database and mapping application available on the Internet. Planners use the tool to digitize projects directly on-line(More)
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