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Transcription factors SOX4 and SOX9 cooperatively control development of bile ducts.
- Alexis Poncy, A. Antoniou, S. Cordi, C. Pierreux, P. Jacquemin, F. Lemaigre
- Medicine, Biology
- Developmental biology
- 15 August 2015
In developing liver, cholangiocytes derive from the hepatoblasts and organize to form the bile ducts. Earlier work has shown that the SRY-related High Mobility Group box transcription factor 9 (SOX9)… Expand
Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning.
UNLABELLED Notch signaling plays an acknowledged role in bile-duct development, but its involvement in cholangiocyte-fate determination remains incompletely understood. We investigated the effects of… Expand
LKB1 and Notch Pathways Interact and Control Biliary Morphogenesis
Background LKB1 is an evolutionary conserved kinase implicated in a wide range of cellular functions including inhibition of cell proliferation, regulation of cell polarity and metabolism. When Lkb1… Expand
MicroRNA‐337‐3p controls hepatobiliary gene expression and transcriptional dynamics during hepatic cell differentiation
Transcriptional networks control the differentiation of the hepatocyte and cholangiocyte lineages from embryonic liver progenitor cells and their subsequent maturation to the adult phenotype.… Expand
Role of the Sox transcription factors in biliary development
Transcription factors SOX4 and SOX9 cooperatively control development of intrahepatic bile ducts
- Alexis Poncy
In developing liver, cholangiocytes derive from the hepatoblasts and organize to form the bile ducts. Earlier work has shown that SOX9 is transiently required for bile duct development, raising the… Expand