Alexis Fuentes

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Saponin-based adjuvants are widely used to enhance humoral and cellular immune responses towards vaccine antigens, although it is not yet completely known how they mediate their stimulatory effects. The aim of this study was to elucidate the mechanism of action of adjuvant Matrix-M™ without antigen and Alum was used as reference adjuvant. Adjuvant Matrix-M™(More)
Information theoretical measures are used to design, from first principles, an objective function that can drive a learning machine process to a solution that is robust to perturbations in parameters. Full analytic derivations are given and tested with computational examples showing that indeed the procedure is successful. The final solution, implemented by(More)
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