Alexis Bozorg Grayeli

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OBJECTIVE To assess the bone density around the bony labyrinth in otosclerosis patients and to compare it to that of a control population. MATERIAL AND METHODS This was a prospective case-control study. Ten patients with otosclerosis (mean age 42 years; range 24-55 years) and 33 control patients with vestibular schwannoma (mean age 46 years; range 20-71(More)
Decision-making criteria for optimal management of meningiomas in neurofibromatosis type 2 (NF2) patients is hampered by lack of robust data, particularly long-term natural history. Seventy-four NF2 patients harboring 287 cranial meningiomas followed up for a mean period of 110.2 months were studied retrospectively. The median number of meningiomas per(More)
OBJECTIVE To evaluate the short-term facial prognostic value of a four-channel facial electromyographic device in vestibular schwannoma surgery. STUDY DESIGN Eighty-nine vestibular schwannomas operated on and intraoperatively monitored by a four-channel facial electromyographic device between October 2002 and September 2003 were included in this(More)
OBJECTIVE/HYPOTHESIS Angiotensin II (Ang II) may be implicated in the regulation of bone remodeling, and its activity is related to several gene polymorphisms including AGT M235T for plasmatic and tissular concentrations of angiotensinogen (AGT), ACE I/D for the angiotensin-converting enzyme activity, and AT(1)R A/C(1166) for the Ang II receptor function.(More)
HYPOTHESIS This study investigates the function of the diastrophic dysplasia sulfate transporter (DTDST) in otosclerotic bone and the effect on it of sodium fluoride (NaF). BACKGROUND Otosclerosis is a localized bone dystrophy with increased bone turnover. DTDST is implicated in the regulation of the bone turnover. MATERIALS AND METHODS Primary cultures(More)
HYPOTHESIS/OBJECTIVE Otosclerosis is a bone remodeling disorder localized to the otic capsule and associated with inflammation. In vitro, increased activity of the diastrophic dysplasia sulfate transporter (DTDST), which is implicated in bone metabolism, has been reported. Because glucocorticoids modulate the bone turnover and inhibit inflammatory(More)
OBJECTIVE To evaluate the results of partial and total ossicular reconstruction prostheses entirely made of hydroxylapatite. STUDY DESIGN A retrospective review of cases followed-up between 1997 and 2000. SETTING Tertiary referral center. PATIENTS One hundred adult patients (60 men and 40 women) were studied. The mean age was 55 years (range, 25 to 65(More)
OBJECTIVE To evaluate the predictive value of electromyographic recordings for the immediate facial nerve outcome after solitary vestibular schwannoma (VS) removal. STUDY DESIGN Prospective cohort study. SETTING Tertiary referral center. PATIENTS AND METHODS From November 2005 to July 2007, 120 operated solitary VSs monitored by NIM Response 2.0(More)
CONCLUSION The retrosigmoid approach for small vestibular schwannomas (VS) yields a high rate of facial function preservation. Hearing preservation rates depend on tumor size and preoperative hearing. OBJECTIVES To report the results and to investigate the prognostic factors for hearing preservation after removal of small VS by a retrosigmoid approach. (More)
OBJECTIVE To evaluate the auditory brainstem implant (ABI) performances in neurofibromatosis type 2 (NF2) and non-NF2 patients. STUDY DESIGN Retrospective cohort study. SETTING Tertiary referral center. PATIENTS Between 1996 and 2006, 31 adult patients (mean age, 41 yr; range, 17-65 yr) were implanted with a 21-electrode Nucleus device (Cochlear Inc.,(More)