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Myosin IIA/IIB restrict adhesive and protrusive signaling to generate front–back polarity in migrating cells
Myosin IIA and IIB synergistically generate front–back polarity through their effects on actomyosin bundling formation and stability, and adhesion maturation, which are mediated by localized Rac GEFExpand
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Integrin-Associated Complexes Form Hierarchically with Variable Stoichiometry in Nascent Adhesions
BACKGROUND A complex network of putative molecular interactions underlies the architecture and function of cell-matrix adhesions. Most of these interactions are implicated from coimmunoprecipitationExpand
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A RIAM/lamellipodin–talin–integrin complex forms the tip of sticky fingers that guide cell migration
The leading edge of migrating cells contains rapidly translocating activated integrins associated with growing actin filaments that form ‘sticky fingers' to sense extracellular matrix and guide cellExpand
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CD81 regulates cell migration through its association with Rac GTPase
Data presented here provide evidence for a new direct interaction of the GTPase Rac with the C-terminal cytoplasmic domain of tetraspanin CD81. Tetraspanin-enriched, microdomain-dependentExpand
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Talin Contains A C-Terminal Calpain2 Cleavage Site Important In Focal Adhesion Dynamics
Talin is a large (∼2540 residues) dimeric adaptor protein that associates with the integrin family of cell adhesion molecules in cell-extracellular matrix junctions (focal adhesions; FAs), where itExpand
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Actin-Based Adhesion Modules Mediate Cell Interactions with the Extracellular Matrix and Neighboring Cells.
Cell adhesions link cells to the extracellular matrix (ECM) and to each other and depend on interactions with the actin cytoskeleton. Both cell-ECM and cell-cell adhesion sites contain discrete, yetExpand
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Fluorescence fluctuation approaches to the study of adhesion and signaling.
Cell-matrix adhesions are large, multimolecular complexes through which cells sense and respond to their environment. They also mediate migration by serving as traction points and signaling centersExpand
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Formation of talin-vinculin pre-complexes dictates maturation of nascent adhesions by accelerated force transmission and vinculin recruitment
Talin, vinculin, and paxillin are mechanosensitive proteins that are recruited early to nascent integrin-based adhesions (NAs). Using machine learning, high-resolution traction force microscopy,Expand
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Breast Cancer Antiestrogen Resistance 3 (BCAR3) – p130Cas Interactions Promote Adhesion Disassembly and Invasion in Breast Cancer Cells
Adhesion turnover is critical for cell motility and invasion. We previously demonstrated that the adaptor molecule breast cancer antiestrogen resistance 3 (BCAR3) promotes adhesion disassembly andExpand
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Abstract B17: A role for the BCAR3/Cas signaling complex in breast tumor progression, metastasis and normal breast morphogenesis
It has long been appreciated that the processes of tissue morphogenesis and tumor initiation/progression share many common features. This is particularly the case for signaling networks involved inExpand