Alexey Sorokin

Learn More
YB-1 is a broad-specificity RNA-binding protein that is involved in regulation of mRNA transcription, splicing, translation, and stability. In both germinal and somatic cells, YB-1 and related proteins are major components of translationally inactive messenger ribonucleoprotein particles (mRNPs) and are mainly responsible for storage of mRNAs in a silent(More)
YB-1 is a universal major protein of cytoplasmic mRNPs, a member of the family of multifunctional cold shock domain proteins (CSD proteins). Depending on its amount on mRNA, YB-1 stimulates or inhibits mRNA translation. In this study, we have analyzed complexes formed in vitro at various YB-1 to mRNA ratios, including those typical for polysomal(More)
The Y-box binding protein 1 (YB-1) is a DNA/RNA-binding nucleocytoplasmic shuttling protein whose regulatory effect on many DNA and RNA-dependent events is determined by its localization in the cell. We have shown previously that YB-1 is cleaved by 20S proteasome between E219 and G220, and the truncated N-terminal YB-1 fragment accumulates in the nuclei of(More)
The pumping lemma and Ogden lemma offer a powerful method to prove that a particular language is not context-free. In 2008 Kanazawa proved an analogue of pumping lemma for well-nested multiple-context free languages. However, the statement of lemma is too weak for practical usage. We prove a stronger variant of pumping lemma and an analogue of Ogden lemma(More)
One way to achieve reliability with low-latency is through multi-path routing and transport protocols that build redundant delivery channels (or data paths) to reduce end-to-end packet losses and retransmis-sions. However, the applicability and effectiveness of such protocols are limited by the topological constraints of the underlying communication(More)