• Publications
  • Influence
Tonically active GABAA receptors: modulating gain and maintaining the tone
GABAA receptors not only respond to the local release of GABA from presynaptic terminals, but can also mediate a persistent 'tonic current'. This reflects the activation of high-affinity GABAAExpand
  • 699
  • 50
GABA uptake regulates cortical excitability via cell type–specific tonic inhibition
GABAA receptors can mediate both 'phasic' synaptic inhibition and a persistent 'tonic' form of signaling. We show that, in the presence of intact GABA uptake, guinea pig hippocampal interneurons, butExpand
  • 394
  • 38
Multiple and Plastic Receptors Mediate Tonic GABAA Receptor Currents in the Hippocampus
Persistent activation of GABAA receptors by extracellular GABA (tonic inhibition) plays a critical role in signal processing and network excitability in the brain. In hippocampal principal cells,Expand
  • 220
  • 17
Modulation of GABAergic Signaling among Interneurons by Metabotropic Glutamate Receptors
Synapses between hippocampal interneurons are an important potential target for modulatory influences that could affect overall network behavior. We report that the selective group III metabotropicExpand
  • 183
  • 14
Kainate receptor-dependent axonal depolarization and action potential initiation in interneurons
Kainate receptor agonists are powerful chemoconvulsants and excitotoxins. These properties are in part explained by depolarization of hippocampal principal neurons. However, kainate also depressesExpand
  • 136
  • 14
Tonic excitation or inhibition is set by GABAA conductance in hippocampal interneurons
Inhibition is a physiological process that decreases the probability of a neuron generating an action potential. The two main mechanisms that have been proposed for inhibition are hyperpolarizationExpand
  • 106
  • 14
Outwardly Rectifying Tonically Active GABAA Receptors in Pyramidal Cells Modulate Neuronal Offset, Not Gain
Hippocampal pyramidal cell excitability is regulated both by fast synaptic inhibition and by tonically active high-affinity extrasynaptic GABAA receptors. The impact of tonic inhibition on neuronalExpand
  • 105
  • 8
Subcellular location of astrocytic calcium stores favors extrasynaptic neuron-astrocyte communication.
Neuron-astrocyte interactions are important for brain computations and synaptic plasticity. Perisynaptic astrocytic processes (PAPs) contain a high density of transporters that are responsible forExpand
  • 73
  • 8
Astrocytic Ca2+ signals are required for the functional integrity of tripartite synapses
BackgroundNeuronal activity alters calcium ion (Ca2+) dynamics in astrocytes, but the physiologic relevance of these changes is controversial. To examine this issue further, we generated an inducibleExpand
  • 83
  • 7
Presynaptic, extrasynaptic and axonal GABAA receptors in the CNS: where and why?
Although GABA(A) receptors are widely distributed at inhibitory synapses on dendrites and cell bodies of neurons, they also occur in other places, in particular at synapses made on axons and inExpand
  • 213
  • 6