Alexey Poyarkov

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Nowadays, the development of most leading web services is controlled by online experiments that qualify and quantify the steady stream of their updates achieving more than a thousand concurrent experiments per day. Despite the increasing need for running more experiments, these services are limited in their user traffic. This situation leads to the problem(More)
Thrombin is a plasma serine protease that plays a key role in coagulation and hemostasis but also in thromboembolic diseases. Direct thrombin inhibitors could be beneficial for future anticoagulant therapy in the prophylaxis of venous and arterial thrombosis as well as myocardial infarction. To design the efficient thrombin inhibitors we have synthesized(More)
INTRODUCTION Plasma serine protease thrombin plays a key role in coagulation, haemostasis and thromboembolic diseases. Direct thrombin inhibitors could be beneficial for future anticoagulant therapy. We have synthesized and studied liporetro-D-peptides - efficient thrombin inhibitors resistant to enzymatic degradation. MATERIALS AND METHODS Compounds(More)
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