Alexey F. Kolomiets

We don’t have enough information about this author to calculate their statistics. If you think this is an error let us know.
Learn More
The system of liver microsomal mixed-function oxygenases participates in the metabolism of fat-soluble xenobiotics, which is accompanied by their conversion to more polar compounds, capable of being excreted from the organisms through the kidneys or through the bile [i]. The central oxygenase in the system of mlcrosomal enzymes is cytochrome P-450 [5]. In(More)
Polyhalogenated dibenzo-p-dioxins (PHDD), formed by alkaline treatment of halo benzenes or halophenols and their ethers, are one of the strongest inducers of microsomal oxygenases [8, 9]. It is thought that the physiological activity of these compounds and the wellknown polycyclic aromatic hydrocarbons (PAH), such as 3-methylcholanthrene, are of the same(More)
A new method for the preparation of alpha-chlorodifluoromethyl-, alpha-bromodifluoromethyl-, and alpha-difluoromethyl-substituted alpha-hydroxy and alpha-amino acid esters 11, 19-21 is described. The key step of the synthesis is the regioselective alkylation of ketones 5, 7-9 and imines 16-18 with C-nucleophiles. The ketones 7-9 are readily available from(More)
  • 1