Structural basis for the recruitment of the human CCR4–NOT deadenylase complex by Tristetraprolin
A high-resolution crystal structure of the TTP–CNOT1 complex was determined, providing the first structural insight into an ARE-binding protein bound to the CCR4–NOT complex, and mutations at the CNOT1-TTP interface impair TTP-mediated deadenylation.
Translation mechanisms involving long-distance base pairing interactions between the 5' and 3' non-translated regions and internal ribosomal entry are conserved for both genomic RNAs of Blackcurrant…
Control of Translation and miRNA-Dependent Repression by a Novel Poly(A) Binding Protein, hnRNP-Q
The heterogeneous nuclear ribonucleoprotein Q2 competitively binds mRNA poly(A) tails to regulate translational and miRNA-related functions of PABP.
The RNA2 5' leader of Blackcurrant reversion virus mediates efficient in vivo translation through an internal ribosomal entry site mechanism.
Multiple RNA2 5' NTR regions, complementary to a fragment of plant 18S rRNA demonstrated previously to be accessible for intermolecular mRNA-rRNA interactions and conserved between eukaryotes, were shown to be important for efficient translation.
Role of the RNA2 3' non-translated region of Blackcurrant reversion nepovirus in translational regulation.
3' TERMINAL SEQUENCE OF BLACKCURRANT REVERSION VIRUS (BRV) RNA2 ARE HIGHLY CONSERVED IN DIFFERENT VIRUS ISOLATES, AND AFFECT ITS TRANSLATIONAL EFFICIENCY
Commentary: Questioning the HIV-AIDS Hypothesis: 30 Years of Dissent
- Alexey E. Karetnikov
- MedicineFrontiers in Public Health
- 7 August 2015
A recent Opinion article by Dr. Goodson (1) expresses pseudoscientific views typical of HIV/AIDS denialism (2–13) and ignores the overwhelming evidence that HIV is a causative agent of AIDS, the…
Relicts and models of the RNA world
Molecular and functional properties of viruses and viroids may be considered as examples or models of the structures and replication mechanisms, which might have been used for the replication of the early biopolymers.