Alexei V Pichugin

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The aim of this study was to evaluate the immunogenicity of NS5A protein of human hepatitis C virus (HCV) when delivered as naked DNA (NS5A DNA), or recombinant protein (rNS5A). DBA/2J mice received NS5A DNA, rNS5A, or NS5A DNA/rNS5A in different prime-boost combinations with a peptidoglycan Immunomax((R)). The weakest response was induced after rNS5A prime(More)
A promising approach to construction of antiviral vaccines consists in activation of cellular immunity with the DNA vaccines. The goal of this work was to evaluate the efficacy of genetic immunization of mice with DNA pcNS3-NS5B encoding five hepatitis C virus (HCV) nonstructural proteins: NS3, NS4A, NS4B, NS5A, and NS5B in comparison with plasmids(More)
The review summarizes information on the role of apoptosis in distinct cell subsets in tuberculosis infection. It is emphasizes that the apoptotic death of Mycobacterium-infected macrophages and immune T cells may have differences for the protection of the host. Macrophageal apoptosis may be considered as an important mechanism involved in defense against(More)
Replication-defective adenoviral vectors are effective molecular tools for both gene therapy and gene vaccination. Using such vectors one can deliver and express target genes in different epithelial, liver, hematopoietic and immune system cells of animal and human origin. The success of gene therapy and gene vaccination depends on the production intensity(More)
AIM To characterize pathogenesis, clinicolaboratory criteria and treatment of postinfection irritable bowel syndrome (PICS). MATERIAL AND METHODS The examination including histological study of the small and large intestine mucosa, polymerase chain reaction (PCR), coagglutination reaction using shigella, salmonella, yersinia, campilobacter jejuni(More)
Of the 29 patients enrolled in the SYNPACE Trial, 15 had had asystolic response (ventricular asystole > 3 seconds) during head-up tilt testing (HUTT). Of these, 8 were randomized to pacemaker On, and 7 to pacemaker OFF. In patients randomized to pacemaker ON, syncope recurred in 4 (50%), whereas, in patients randomized to pacemaker OFF, syncope recurred in(More)
AIM A detailed description of immune status abnormalities of adult patients with heart arrhythmia either idiopathic or in combination with primary heart disease such as chronic myocarditis and dilated cardiomyopathy (DCMP). MATERIAL AND METHODS Eighty two consecutive patients aged 16-57 years admitted to the L.A. Myasnikov Institute of Clinical Cardiology(More)
The efficacy of the Gepon immunomodulator was studied in 36 patients with ulcerative colitis (UC) having distal lesions in the resistant form. Taking into account the fact that immunological abnormalities play the main role in UC pathogenesis, the drug with immunomodulatory action was used for overcoming resistance to basic anti-inflammatory drugs. The(More)
This paper describes the results of an original study into the systemic and local immunity in 25 patients with trophic venous ulcers. The authors discovered a number of significant parameters demonstrating the influence of the immune status on the formation of venous ulcers and tempo of their healing. They revealed previously unknown relationships between(More)
Omeprazole is among the most effective antisecretory preparations used for the treatment of peptic and duodenal ulcers. The drug is available in the form of capsules under the trade names losec, omez, omezole, gastrozole, etc. Omeprazole-akri (Akrikhin, Russia) is a new domestic generic preparation dosed as 20 mg omeprazole per intestine-soluble pellet. The(More)
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