Alexei Umriukhin

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Nonalcoholic fatty liver disease, induced by a Western diet (WD), evokes central and peripheral inflammation that is accompanied by altered emotionality. These changes can be associated with abnormalities in social behaviour, hippocampus-dependent cognitive functions, and metabolism. Female C57BL/6J mice were fed with a regular chow or with a WD containing(More)
Microdialysis for measurement of serotonin in the paraventricular nucleus of the hypothalamus (PVN) and the dorsal hippocampus was performed under both basal and stimulated conditions, known to elicit differential behavioral and neuroendocrine responses in rats with inborn high (HAB) or low (LAB) anxiety-related behavior. We studied the release of(More)
While rodents have a keen sense of smell and largely depend on olfactory cues for operating in their environment, most of the widely used tests to assess anxiety-related behavior largely ignore the olfactory system, being primarily based on fear of brightly lit, novel and open spaces. Here, we aimed at testing whether the genetic predisposition to anxiety(More)
The influence of exposure to immobilization stress on TNF alpha and IL-4 concentrations in blood was studied in behaviorally active vs. passive in the open field Wistar rats. One hour after exposure to stress, blood concentrations of TNF alpha and IL-4 were significantly lower in behaviorally passive as compared to active rats and passive controls not(More)
The aim of the work was to study effect of peripheral administration of mu-opioid receptor ligands unable to penetrate through the hematoencephalic barrier on the measures of emotionality in rats and on the release of beta-endorphins from nerve endings of the anterior cingulate cortex during emotional stress. The mu-opioid receptor agonist loperimide mostly(More)
A13 Interactions of peripheral and central μ opioid systems during emotional stress Valentina Bashkatova, Helmut Prast, Alexei Umriukhin and Sergey Sudakov Department of Reinforcement Physiology, P.K. Anokhin Research Institute of Normal Physiology RAMS, 125315 Moscow, Russia Department of Pharmacology and Toxicology, University of Innsbruck, 6020(More)
Background Numerous studies support an important contribution of endogenous opioid peptide systems in the mechanisms of emotional behavior. It is well known that the structure of opioid receptors (OR) and endogenous opioid peptides in the CNS and in the periphery is identical, but the central and peripheral functions of endogenous opioid systems are(More)
The work is devoted to the research of immune mechanisms in self-control of various functional systems of homeostatic and behavioral levels. Distinction of immune mechanisms in rats with different prognostic stress-resistance is established. Immunization of rats by conjugates of various neuromediators with bovine serum albumin selectively changes the(More)
Preliminary data indicate that increased blood plasma level of β-endorphin in patients with nonpsychotic unipolar depression after 2 weeks of treatment correlates with the positive response to therapy. This parameter can be regarded as an objective indicator of potential improvements. Further studies aimed at determining the value of blood β-endorphin(More)
Serotonin contents in the paraventricular hypothalamic nucleus (PVN) and dorsal hippocampus of rats with different levels of inborn motor activity were studied by microdialysis in basal and stimulated conditions. Rats were exposed to elevated platform and forced swimming stress. In basal conditions, differences in serotonin contents between rats with(More)