Alexandru T Constantinescu

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Caenorhabditis elegans embryos establish cortical domains of PAR proteins of reproducible size before asymmetric cell division. The ways in which the size of these domains is set remain unknown. Here we identify the GTPase-activating proteins (GAPs) RGA-3 and RGA-4, which regulate the activity of the small GTPase RHO-1. rga-3/4(RNAi) embryos have a(More)
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder in industrialized countries. Present cell culture models for PD rely on either primary cells or immortal cell lines, neither of which allow for long-term experiments on a constant population, a crucial requisite for a realistic model of slowly progressing neurodegenerative(More)
Recombinant annexin V (rAnV) has been used in flow cytometry to identify cells undergoing apoptosis, based on its ability to bind to phosphatidylserine, a negatively charged lipid normally restricted to the cytoplasmic face of the plasma membrane but externalized early during apoptosis. When we stained murine bone marrow (BM) cells with fluorescently(More)
The authors T.Harima, J.C.Migliore, U.Nagel and J.Watanabe characterize in [8] the Hilbert function of algbebras with the Lefschetz property. We extend this characterization to algebras with the Lefschetz property m times. We also give upper bounds for the Betti numbers of Artinian algebras with a given Hilbert function and with the Lef-schetz property m(More)
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