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Intraflagellar transport (IFT) depends on two evolutionarily conserved modules, subcomplexes A (IFT-A) and B (IFT-B), to drive ciliary assembly and maintenance. All six IFT-A components and their motor protein, DYNC2H1, have been linked to human skeletal ciliopathies, including asphyxiating thoracic dystrophy (ATD; also known as Jeune syndrome),(More)
Functional and immunocytochemical studies indicate that intercalated cells in the adult rabbit cortical collecting duct (CCD) possess an H-K-adenosinetriphosphatase (H-K-ATPase). Because growing subjects must retain K+ and excrete H+, we sought to determine whether H-K-ATPase is present in the CCD early in life and, if so, to assess its activity and(More)
Within the renal cortical collecting duct (CCD), transepithelial Na(+) absorption and K(+) secretion are linked to basolateral Na(+)-K(+)-ATPase activity. Our purpose was to examine the developmental changes in basolateral Na(+)-K(+)-ATPase-mediated (86)rubidium (Rb) uptake, its inhibitor sensitivity and relationship to pump hydrolytic activity and Na(+)(More)
Calcium(Ca2+)-dependent processes mediate, in part, anoxic cell injury. These may account for the difference in sensitivity to anoxia between certain immature and mature renal cells. To address this question, we studied the effects of anoxia on cytosolic free Ca2+ concentration ([Ca2+]i), cell integrity, and transport functions in micro-dissected proximal(More)
It has been known for some time that the exchange-correlation potential in time-dependent density-functional theory is an intrinsically nonlocal functional of the density as soon as one goes beyond the adiabatic approximation. In this paper we show that a much more severe nonlocality problem, with a completely different physical origin, plagues the(More)
The authors T.Harima, J.C.Migliore, U.Nagel and J.Watanabe characterize in [8] the Hilbert function of algbebras with the Lefschetz property. We extend this characterization to algebras with the Lefschetz property m times. We also give upper bounds for the Betti numbers of Artinian algebras with a given Hilbert function and with the Lef-schetz property m(More)
We report for the first time the case of a 3-year-old girl who developed a severe anaphylactoid reaction following the administration of the nonionic, low osmolar intravenous radiographic contrast agent ioversol. Severe reactions to ioversol have rarely been reported in adult patients and to our knowledge never in children. Health care providers managing(More)
Asiri S. Abeyagunawardena Carolyn L. Abitbol Peter Abt Gian Luigi Adani Raymond D. Adelman Dwomoa Adu Rekha Agrawal Sarah W. Alexander Steven R. Alexander Uri S. Alon Dominik M. Alscher Amira Al-Uzri Ofelia Alvarez Kerstin Amann Alessandro Amore John M. Andersen Nigel G. Anderson Sharon Anderson Jean-Luc André Sharon Andreoli Styliani Andronikou Franca(More)