Alexandru Pîrvan

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BACKGROUND According to the 2008 celiac disease working group run by Dr. A. Fassano under the auspices of the Federation of International Societies of Pediatric Gastroenterology, Hepatology and Nutrition, celiac disease is a chronic immune-mediated enteropathy characterized by gluten sensitivity, which can affect any organ or system, having a wide range of(More)
AIMS Pill-induced esophagitis has been recognized in adults, but rarely in children. The aim of this article is to discuss endoscopic features, drugs implicated, prevention and treatment in pill-induced esophagitis in children. PATIENTS AND METHODS Over a period of 4 years, 26 patients presented at our clinic with drug-induced esophageal ulcerations. All(More)
Anti-actin antibodies are found in 52-85% of patients with autoimmune hepatitis or chronic active hepatitis and in 22% of patients with primary biliary cirrhosis. In patients with celiac disease, anti-actin antibodies correlate with the degree of villous atrophy. Studies on their involvement in celiac disease and dermatitis herpetiformis in Romania have not(More)
OBJECTIVES The objective of this study was to asses the prevalence of atrophic gastritis in children. We also wanted to compare the clinical manifestation, endoscopic appearance and the degree of the gastric atrophy in children and to identify the possible causes which determine gastric atrophy. METHODS We evaluated 247 children with chronic gastritis(More)
Diagnosis of celiac disease in a patient with lactose intolerance has special importance having implications for the treatment of both diseases. The authors present the case of a 2 years old girl, first diagnosed with enterocolitis, but her clinical evolution revealed a complex situation: both celiac disease and secondary lactose intolerance. We present the(More)
Partial trisomy 9q represents a rare and heterogeneous group of chromosomal aberrations characterised by various clinical features. Associated clinical features include learning disability and pyloric stenosis. In this paper we present a 5 months old female patient with different dysmorphic features due to excess of genetic material on the long arm of(More)
Celiac disease percentage is continuously increasing in recent years. Helicobacter pylori infection is found in more than 50% of the population. Recent studies have attempted to discover a link between celiac disease and H. pylori infection. We analyzed the main immunopathological aspects of celiac disease associated with H. pylori infection. If celiac(More)
The latest consensus on celiac disease in 2008, under the auspices of the International Societies of Pediatric Gastroenterology, Hepatology and Nutrition, shows that HLA DQ2/DQ8 typing indicates the highest negative predictive value for celiac disease, which would exclude the diagnosis of celiac disease. In Romania, there are no studies on the implication(More)
The prevalence of coeliac disease (CD) in systemic lupus erythematosus (SLE) is unclear since evidence of this co -association is scarce. Furthermore, CD -specific antibodies have been described in patients with SLE without biopsy -confirmed CD. Here we describe the diagnostic challenges of CD in a patient suffering from SLE and secondary antiphospholipid(More)