Alexandre Todorovic Fabro

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The objectives of this study were to evaluate morphologic alterations and precancerous lesions in Reinke's edema. Patients included were 54 smokers with bilateral Reinke's edema submitted to surgery in the Otolaryngology Department, Botucatu Medical School, São Paulo State University, Brazil, between 2002 and 2006. All specimens were evaluated by light(More)
UNLABELLED Reinke's edema is chronic laryngeal disease in which the superficial layer of the lamina propria is expanded by thick mucus, giving it a gelatin aspect. The disease is directly related to smoking and more frequent in women, who end up having a lower tone of voice. Its histological characteristics cannot always distinguish it from other benign(More)
OBJECTIVE To study the clinical, radiological, and histopathological patterns of transbronchial biopsy (TBB) used in order to confirm the diagnosis in patients with clinical suspicion of interstitial lung disease (ILD) treated at a tertiary-care university hospital. METHODS We reviewed the medical records, radiology reports, and reports of transbronchial(More)
OBJECTIVE To evaluate the prevalence of cardiovascular events (CVE) secondary to atherosclerosis in lupus patients and correlate them to the traditional risk factors, disease duration and drug therapy used. METHODS A retrospective study was carried out based on data obtained from patients charts. Patients included were those who had a lupus diagnosis(More)
UNLABELLED Granulomas are bilateral and pediculated lesions of the vocal apophysis. Etiologies: intubation, reflux, trauma, vocal abuse, idiopathic origin. AIM To analyze the clinical and morphological aspects of post intubation granulomas. METHODS retrospective study of patients submitted to microsurgery for post intubation laryngeal granulomas seen at(More)
BACKGROUND Myofibroblasts derived from fibroblasts in the pathogenesis of pulmonary fibrosis causes excessive and disordered deposition of matrix proteins, including collagen V, which can cause a Th17-mediated immune response and lead to apoptosis. However, whether the intrinsic ability of lung FBs to produce the matrix depends on their site-specific(More)
OBJECTIVE To increase the knowledge base regarding pulmonology research in Brazil. METHODS A retrospective, observational study of the abstracts published in the Annals of the Brazilian Pulmonology and Phthisiology Conferences held from 1986 to 2004, quantifying the institutions of origin by geographic distribution and type, as well as categorizing the(More)
Neurocysticercosis is a major public health concern. Although its eradication appears feasible, the disease remains endemic in developing countries and has emerged again in Europe and in the USA. Basic studies on neurocysticercosis are needed to better understand the pathophysiologic mechanisms and, consequently, to improve treatment perspectives. Much has(More)
OBJECTIVES To analyze the hyaluronic acid behavior in the lamina propria of the larynx with advancing age. STUDY DESIGN Prospective study. SETTING UNESP-Univ Estadual Paulista, Botucatu Medical School, Brazil. SUBJECTS AND METHODS Thirty vocal folds were obtained at necropsy from 10 adult males (30-50 years old) and 20 geriatric males (10: 60-75 years(More)
This work investigates structural wave propagation in waveguides with randomly varying properties along the axis of propagation, specifically when the properties vary slowly enough such that there is negligible backscattering. Wave-based methods are typically applied to homogeneous waveguides but the WKB (after Wentzel, Kramers and Brillouin) approximation(More)