Alexandre M. Erkine

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Tamara Y. Erkina2
Daniel J. Williams1
Ivan Dixon1
Levi M. Smith1
2Tamara Y. Erkina
1Daniel J. Williams
1Ivan Dixon
1Levi M. Smith
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After more than three decades since the discovery of transcription activation domains (ADs) in gene-specific activators, the mechanism of their function remains enigmatic. The widely accepted model of direct recruitment by ADs of co-activators and basal transcriptional machinery components, however, is not always compatible with the short size yet very high(More)
  • Levi M. Smith, Dwipayan Bhattacharya, Daniel J. Williams, Ivan Dixon, Nicholas R. Powell, Tamara Y. Erkina +1 other
  • 2015
Development of novel anti-cancer drug leads that target regulators of protein homeostasis is a formidable task in modern pharmacology. Finding specific inhibitors of human Heat Shock Factor 1 (hHSF1) has proven to be a challenging task, while screening for inhibitors of human Heat Shock Factor 2 (hHSF2) has never been described. We report the development of(More)
Cellular stress responses are characterized by coordinated transcriptional induction of genes encoding a group of conserved proteins known as molecular chaperones, most of which are also known as heat shock proteins (HSPs). In S. cerevisiae, transcriptional responses to stress are mediated via two trans-regulatory activators: heat shock transcription(More)
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