In the present work we explored cellular sites of interleukin-6 (IL-6) biosynthesis in human follicular aspirates from patients undergoing in vitro fertilization therapy and the effects of this cytokine on oocyte fertilization and granulosa cell (GC) steroidogenesis. Biological IL-6 activity from 20-40 IU/mL was present in follicular fluids from 22… (More)
Dab1(scm) mutant mice, characterized by cell ectopias and degeneration in cerebellum, hippocampus, and neocortex, were compared to non-ataxic controls for different facets of grooming caused by brief water immersions, as well as some non-grooming behaviors. Dab1(scm) mutants were strongly affected in their quantitative functional parameters, exhibiting… (More)
In the rat's anterior pituitary, mitoses occur to be side by side, forming "pairs", the frequency of which is significant all the more as their number is underrated in sections. In 85% of the pairs the mitoses are synchronous. These paired synchronous mitoses are suggestive of the existence of cellular clones in the pituitary.