Alexandre Le Bouthillier

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This paper presents a parallel cooperative multi-search method for the vehicle routing problem with time windows. It is based on the solution warehouse strategy, in which several search threads cooperate by asynchronously exchanging information on the best solutions identi0ed. The exchanges are performed through a mechanism, called solution warehouse, which(More)
We have developed a pattern-identification mechanism that endows cooperative search with capabilities to create new information and guide the global search. The proposed mechanism sends information to independent metaheuristics about promising and unpromising patterns in the solution space. By fixing or prohibiting specific solution attribute values in(More)
BACKGROUND AND PURPOSE Endothelin-1 (ET) has been shown to be involved in human pathological conditions, but its physiological function remains to be elucidated. The aim of this work was to assess whether endothelium-derived ET was involved in the overall responsiveness of freshly isolated human pial arteries. METHODS Samples of cerebral cortex, otherwise(More)
Acute benzodiazepine administration has been reported to antagonize the effect of cholecystokinin both in the periphery and in the central nervous system. A two-week treatment with either diazepam (5 mg/kg per day) or flurazepam (15 mg/kg per day) markedly reduced the excitatory effect of microiontophoretically applied sulphated cholecystokinin(More)
Long-term administration of various types of antidepressant drugs has been recently reported to reduce the density of benzodiazepine receptors in the rat CNS. In the present study, using the microiontophoretic technique, the effect of flurazepam application on cholecystokinin-induced activation of hippocampal pyramidal neurons was assessed in rats treated(More)
Advanced Heuristics in Transportation and Logistics “Advanced Heuristics in Transportation and Logistics” [Guest Editors’ Introduction], Christos D. Tarantilis, Diomidis Spinellis, and Michel Gendreau, July/ Aug., pp. 16–18. “Case Study: An Intelligent Decision-Support System,” Zbigniew Michalewicz, Martin Schmidt, Matthew Michalewicz, and Constantin(More)
The vehicle routing problem with time windows (VRPTW) is a representation of a wellknown transportation problem. It involves customers, depot, vehicles and constraints on delivery time (time windows) and capacity on vehicles. To minimize cost, the solution of a VRPTW problem must satisfy all the constraints while minimising the total distance for the lowest(More)
As transportation problems grow larger with the new world economy, so do the problem size and complexity. To be able to produce consistent solutions, individual solving methods tends to be very complex. Also, a compromise between solution quality and computing time needs to be reached. Transportation problems such as Vehicle Routing Problem with Time(More)
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