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  • Alexandre Briguet, Michael Erb, +11 authors Thomas W. Meier
  • Medicine, Biology
  • FASEB journal : official publication of the…
  • 2008 (First Publication: 1 December 2008)
  • Dystrophin deficiency is the underlying molecular cause of progressive muscle weakness observed in Duchenne muscular dystrophy (DMD). Loss of functional dystrophin leads to elevated levels ofContinue Reading
  • Alexandre Briguet, Dorothee Bleckmann, Mickaël Bettan, Nicolas Mermod, Thomas W. Meier
  • Medicine, Biology
  • Neuromuscular Disorders
  • 2003 (First Publication: 1 February 2003)
  • Duchenne muscular dystrophy is an X-linked genetic disease caused by the absence of functional dystrophin. Pharmacological upregulation of utrophin, the autosomal homologue of dystrophin, offers aContinue Reading
  • Cyrille Lescop, Holger Herzner, +10 authors Andreas von Sprecher
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2005 (First Publication: 1 December 2005)
  • Dipeptide-derived alpha-keto-amide compounds with potent calpain inhibitory activity have been identified. These reversible covalent inhibitors have IC(50) values down to 25nM and exhibit greatlyContinue Reading