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Epidemiological studies have repeatedly found that whole-grain (WG) cereal foods reduce the risk of several lifestyle-related diseases, though consistent clinical outcomes and mechanisms are elusive. To compare the effects of a WG-rich diet with a matched refined-grain (RG) diet on plasma biomarkers and bowel health parameters, seventeen healthy subjects(More)
Estimation of whole-grain (WG) food intake in epidemiological and nutritional studies is normally based on general diet FFQ, which are not designed to specifically capture WG intake. To estimate WG cereal intake, we developed a forty-three-item FFQ focused on cereal product intake over the past month. We validated this questionnaire against a 3-d-weighed(More)
BACKGROUND To our knowledge, there is no direct information on lycopene metabolism in humans. OBJECTIVE The objective of this study was to quantify the long-term human bioavailability of lycopene in plasma and skin after a single dose of (14)C-lycopene and to profile the metabolites formed. DESIGN We preselected 2 male subjects as lycopene absorbers and(More)
BACKGROUND Small-scale, short-term intervention studies have suggested that plasma alkylresorcinol (AR) concentrations may be biomarkers of whole grain (WG) wheat and rye intakes. OBJECTIVE The objective was to determine whether plasma AR concentrations reflect self-reported WG food intake in a 16-wk WG intervention study and to establish which phenotypic(More)
Endosomal-autophagic-lysosomal (EAL) dysfunction is an early and prominent neuropathological feature of Alzheimers’s disease, yet the exact molecular mechanisms contributing to this pathology remain undefined. By combined biochemical, immunohistochemical and ultrastructural approaches, we demonstrate a link between EAL pathology and the intraneuronal(More)
Erythrocyte alkylresorcinols (5-alkyl-1,3-dihydroxybenzenes) are potential biomarkers of wholegrain wheat and rye intake. However, their high-throughput quantitative analysis by gas chromatography/mass spectrometry (GC/MS) is hindered by the time-consuming sample preparation and, more importantly, by interfering compounds that still remain after sample(More)
BACKGROUND Mitophagy and mitochondrial dynamics alterations are two major hallmarks of neurodegenerative diseases. Dysfunctional mitochondria accumulate in Alzheimer's disease-affected brains by yet unexplained mechanisms. METHODS We combined cell biology, molecular biology, and pharmacological approaches to unravel a novel molecular pathway by which(More)
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