Alexandre Antunes Brum

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Background Caseous lymphadenitis (CLA) is a disease caused by the bacteria Corynebacterium pseudotuberculosis which affects small ruminants such as sheeps and goats, leading to severe economic losses. The development of more sensitive and specific diagnoses showing effectiveness on asymptomatic animals is essential for disease's control. This study purposes(More)
PURPOSE We tested the efficacy of the esterase encoded by cp1002_RS09720 from Corynebacteriumpseudotuberculosis in recombinant subunit and DNA caseous lymphadenitis (CLA) vaccines. This target was predicted as one of the best CLA vaccine candidates by mature epitope density analysis. METHODOLOGY Gene cp1002_RS09720 was cloned into two different vectors(More)
The caseous lymphadenitis (CLA) is a common disease that affects ruminants around the world. The CLA is caused by gram-positive bacteria known as Corynebac-terium pseudotuberculosis, which is an intracellular facultative pathogen. In Brazil, the high prevalence occurs principally in northeast and southwest, where has the major herd of sheep and goat causing(More)
Caseous lymphadenitis (CLA) is a disease caused by Corynebacterium pseudotuberculosis. It affects mainly small ruminants and causes significant economic losses worldwide. Because symptoms are not immediately noticeable, CLA clinical diagnosis is not effective. Numerous serological tests are being developed to detect the disease in asymptomatic animals, but(More)
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