Alexandra Winter

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BACKGROUND Mutation of the cystic fibrosis transmembrane-conductance regulator (CFTR) causes cystic fibrosis (CF) but not all CF aspects can easily be explained by deficient ion transport. CF-inflammation provides one example but its pathogenesis remains controversial. Here, we tested the simple but fundamental hypothesis that wild-type CFTR is needed to(More)
Background: Mutation of the cystic fibrosis transmembrane-conductance regulator (CFTR) causes cystic fibrosis (CF) but not all CF aspects can easily be explained by deficient ion transport. CF-inflammation provides one example but its pathogenesis remains controversial. Here, we tested the simple but fundamental hypothesis that wild-type CFTR is needed to(More)
The domain of hemato-oncology is characterized by a complex and data-intensive treatment and the involvement of geographically distributed institutions (e.g. oncological ward, central commission, external panels) in the context of protocol-directed trials. Current research efforts in this domain (e.g. [1-3]) focus on specialized subtasks such as(More)
Despite a plethora of recommendations for personalization techniques, such approaches often lack empirical justification and their benefits to users remain obscure. The study described in this paper takes a step towards filling this gap by introducing an evidence-based approach for deriving adaptive interaction techniques. In a dialogue experiment with 36(More)
The IBM System z9e introduces the enhanced book availability (EBA) feature to reduce the number of planned system outages. Included as part of the EBA feature is the concurrent book replacement (CBR) function, which allows a single book in a multi-book server to be concurrently removed from the system in order for service personnel to perform a repair or to(More)
♦ BACKGROUND: Intraperitoneal administration of antimicrobial agents is recommended for the treatment of peritoneal dialysis (PD)-related peritonitis. For home-based antimicrobial therapy it is common to supply patients with PD fluid bags with admixed antibiotic. Thus, the compatibility of meropenem with different PD fluids (PDFs), namely Extraneal,(More)
The domain of hemato-oncology is characterized by a complex patient management and the involvement of several institutions (e.g. oncological ward, private practitioner, external review panels) in the context of protocol-directed trials. Current research efforts in this domain (e.g. [1-3]) focus on specialized subtasks such as chemotherapy dose calculation(More)
Using scientific methods in the humanities is at the forefront of objective literary analysis. However, processing big data is particularly complex when the subject matter is qualitative rather than numerical. Large volumes of text require specialized tools to produce quantifiable data from ideas and sentiments. Our team researched the extent to which tools(More)
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