Alexandra W-A H Chisholm

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FRIEDREICH 'S ATAXIA is one of the rare heritable spinocerebellar degenerations. The spinocerebellar tracts, dorsal columns, pyramidal tracts, and, to a lesser extent, the cerebellum and medulla are involved. The disorder is usually manifest before adolescence and is generally characterized by incoordination of limb movements, dysarthria, nystagmus,(More)
BACKGROUND Weight regain often occurs after weight loss in overweight individuals. We aimed to compare the effectiveness of 2 support programs and 2 diets of different macronutrient compositions intended to facilitate long-term weight maintenance. METHODS Using a 2 x 2 factorial design, we randomly assigned 200 women who had lost 5% or more of their(More)
1. Thirty-two patients (29 men and 3 women), admitted to a coronary-care unit with either acute coronary insufficiency or acute myocardial infarction, had their systolic time intervals and the a/E ratio of the apexcardiogram studied on days 1,2, and 7 of their hospital stay. 2. Only the LVETc and PEP/LVET were found to undergo any statistically significant(More)
AN INCREASE in the magnitude of splitting of the 2 components of the second heart sound, as heard in the pulmonary area during inspiration, has been recognized for nearly a century.1 Recent reports2' 3 suggest that this phenomenon is due to a relative delay of pulmonary valve closure when the increased venous return during inspiration causes prolongation of(More)
BACKGROUND AND AIMS Some individuals respond to a greater extent than others to changes in dietary fat and cholesterol even when dietary intake is consistent. A prospective study has been undertaken in which two groups of individuals according to cholesteryl ester transfer protein (CETP) genotype were compared in terms of plasma lipid response to altering(More)
Amiodarone hydrochloride, a new antiarrhythmic agent, controlled a recurrent supraventricular arrhythmia, refractory to conventional medical treatment, in a 57-year-old patient with an anomalous conduction system and idiopathic cardiomyopathy. For the 11 months that the patient has been taking the drug her arrhythmia has not recurred. This drug has produced(More)
Thirty-five patients were implanted with the Sequicor DDD pacemaker between September 1, 1981 and March 1, 1982. The mean age was 61.7 years (range, 17-88). According to their ECGs, the patients fell into two distinct groups--those with A-V block and those with sick sinus syndrome. Our initial experience has indicated an excellent electronic component(More)
Ten patients, representing 1.34 per cent of those patients undergoing selective coronary arteriography, were found to have unequivocal evidence of coronary artery spasm. This involved the proximal right coronary artery in eight patients, the mid-left anterior descending branch in one, and the left main coronary artery in one. Eight of these 10 patients had(More)