Alexandra V. Kim

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The objective of the present work was to study the distribution of tetramethylthiuram disulfide (TMTD) in the body of warm-blooded animals as exemplified by white rats. TMTD was administered intragastrically and detected in the unaltered form in other internal organs. It was found to accumulate in the largest amounts in the gastric contents, kidneys, and(More)
A simple formalism is proposed for a quantitative analysis of interatomic voids inside and outside of a molecule in solution. It can be applied for the interpretation of volumetric data, obtained in studies of protein folding in water. The method is based on the Voronoi-Delaunay tessellation of molecular-dynamic models of solutions. It is suggested to(More)
We study the structure of computer models of liquid cyclohexane and its noncyclic analogue 2,3-dimethylbutane. It is shown that regardless of the different chemical structure of these molecules, they both behave in liquid like spherical particles. It emerges insimilarity of pair correlation functions calculated forcenters of mass of molecules with the(More)
Glycyrrhizic acid (GA) is a triterpene glycoside extracted from licorice root. Due to its amphiphilicity GA is capable of forming complexes with a variety of hydrophobic molecules, substantially increasing their solubility. GA can enhance the therapeutic effects of various drugs. It was hypothesized that the increased bioavailability of the drug by GA is(More)
Recently a simple formalism was proposed for a quantitative analysis of interatomic voids inside a solute molecule and in the surrounding solvent. It is based on the Voronoi-Delaunay tessellation of structures, obtained in molecular simulations: successive Voronoi shells are constructed, starting from the interface between the solute molecule and the(More)
Optimal conditions for the extraction of tetramethyltiuram disulfide (TMTD) from biological materials with ethylacetate are described. The isolated compound can be separated from co-extracted impurities on a silicagel L (40/100 mcm) column. Identification and quantitative determination of TMTD purified from cadaverous liver were performed using thin-layer(More)
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