Alexandra Steinberg

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OBJECTIVE Arhalofenate (ARH), in development for gout, has uricosuric and anti-flare activities. ARH plus febuxostat (FBX) were evaluated in subjects with gout for serum uric acid (SUA) lowering, drug interaction, and safety. METHODS Open phase II trial in gout volunteers (NCT02252835). Cohort 1 received ARH 600 mg for 2 weeks, followed by sequential(More)
There is a general consensus that networks and community interaction provide a critical mechanism for innovation. Of recent years we have seen a growth of interest in the role of social networks, partly fuelled by the fact that the contemporary business world has become more dynamic, complex and global. Today an increasing number of people work in(More)
OBJECTIVE Arhalofenate is a novel antiinflammatory uricosuric agent. The objective of this study was to evaluate its antiflare activity in patients with gout. METHODS This was a 12-week, randomized, double-blind, controlled phase IIb study. Eligible patients had had ≥3 flares of gout during the previous year, had discontinued urate-lowering therapy and(More)
This chapter introduces the work of Deleuze and Guattari, particularly their notion of rhizomic becomings to the study of emergent knowledge dynamics in contexts of innovation. It shows how an analysis of rhizomic becomings can assist to explore new and emergent patterns, channelling interpretation toward the discovery of new combinations and creative(More)
absTraCT There is a general consensus that networks and community interaction provide a critical mechanism for innovation. Of recent years, we have seen a growth of interest in the role of social networks, partly fuelled by the fact that the contemporary business world has become more dynamic, complex, and global. Today an increasing number of people work(More)
6578 Background: Myeloablative hematopoietic cell transplant (HCT) for leukemia/lymphoma is highly toxic and often not well tolerated. Total lymphoid irradiation and antithymocyte globulin (TLI-ATG) is a nonmyeloablative (NMA) stem cell therapy developed at Stanford that protects against GVHD by increasing T-reg proportion. We have incorporated TLI-ATG as(More)
The dotcom crash presented new challenges to successful business and decision-making in e-entrepreneurship, the implications of which can be better understood by looking at the changing meanings of expert knowledge and of business community. This is one of the main findings of a case study on e-entrepreneurship in the Greater London business area. Using a(More)
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