Alexandra Schumann

Learn More
Liver transplantation is often the ultimate option of therapy for chronically hepatitis B virus (HBV) infected patients. Adoptive transfer of HBV immunity with the liver after vaccination of living liver donors (LLD) could be a new approach to prevent reinfection in the recipients. The time to achieve HBV immunity in LLD is usually short (1-2 months).(More)
Hepatitis D virus (HDV) superinfection of hepatitis B virus (HBV) carriers causes severe liver disease and a high rate of chronicity. Therefore, a vaccine protecting HBV carriers from HDV superinfection is needed. To protect from HDV infection an induction of virus-specific T cells is required, as antibodies to the two proteins of HDV, p24 and p27, do not(More)
Protection of hematopoietic stem cell recipients from infection remains challenging because of severe immunosuppression after transplantation. In patients with hepatitis B virus (HBV) infection prior to transplantation, the risk of HBV reactivation 5 years after transplantation was 70–86%. To overcome HBV reactivation, active immunization of donors and(More)
BACKGROUND Liver transplantation is often the ultimate option of therapy for chronically hepatitis B virus (HBV) infected patients. Prevention of reinfection is therapy intensive and cost-effective. Adoptive transfer of HBV-specific immunity with the liver from an immune living liver donor (LLD) could be a new approach to prevent reinfection. METHODS(More)
BACKGROUND Blood donors with indeterminate hepatitis C virus antibody (anti-HCV) reactivity are rejected from blood donation. As they are mostly nonviremic, the source of these reactions remains unclear. Reasons for such findings can be resolved HCV infections as well as unspecific antibody reactions. The aim of this study was to investigate HCV-specific(More)
Artificial dipolar spin-ice patterns have attracted much attention recently because of their rich configurations and excitations in the form of Dirac strings connecting magnetic monopoles. We have analysed the distribution of excitations in the form of strings and vertices carrying magnetic charges Q=±3q in honeycomb artificial spin-ice patterns. Two types(More)
This report describes how donor- and recipient-derived immunity was influenced by immunosuppressive treatment of ABO incompatibility (rituximab and immunoadsorption/plasmaphereses) in the long-term. We present an 8-year course of Hepatitis B virus (HBV) immunity, isohemagglutinins and B cell numbers. Whereas cellular HBV immunity was transferred from the(More)
  • 1