Alexandra Pohl

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Purpose: Previous studies have shown that estrogen prevents colon cancer in post-menopausal women, indicating a role in colorectal cancer carcinogenesis and tumor progression. We investigated the interactions between sex, age, ethnicity, and year of diagnosis on overall survival (OS) in patients with metastatic colorectal cancer (MCRC). Experimental Design:(More)
abstract Media are " [media] means effecting or conveying something such as (1) a surrounding or enveloping substance; or (2) a condition or environment in which BLOCKINsomething BLOCKINmay BLOCKINfunction BLOCKINor BLOCKINflourish; BLOCKINor BLOCKIN(3) mode of artistic expression or communication. " (Merriam-Webster, n.d.) In the case of ambient media, the(More)
Recent studies suggest CD133, a surface protein widely used for isolation of colon cancer stem cells, to be associated with tumor angiogenesis and recurrence. We hypothesized that gene expression levels and germline variations in CD133 will predict clinical outcome in patients with metastatic colorectal cancer (mCRC), treated in first-line setting with(More)
Inactivated vaccines are commonly produced by incubating pathogens with chemicals such as formaldehyde or β-propiolactone. This is a time-consuming process, the inactivation efficiency displays high variability and extensive downstream procedures are often required. Moreover, application of chemicals alters the antigenic components of the viruses or(More)
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