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The primary function of the presynaptic nerve terminal is to release transmitter quanta and thus activate the postsynaptic target cell. In almost every step leading to the release of transmitter quanta, there is a substantial involvement of ion channels. In this review, the multitude of ion channels in the presynaptic terminal are surveyed. There are at(More)
Acknowledgements From its inception this report has benefited from a great deal of support and advice. We are grateful to many reviewers who provided invaluable advice and comments on successive drafts of the paper: We are also immensely grateful to staff at the Danish Ministry of Foreign Affairs who helped to define and direct the project, provided(More)
1. We used a preparation of fused presynaptic nerve terminals of Torpedo electromotor nerve and the patch-clamp technique for characterization of single ion channels. We report here of a large, nonselective ion channel which is highly voltage dependent. 2. The slope conductance of the I-V relation was estimated by either direct measurement of the(More)
Acknowledgements From its inception this report has benefited from a great deal of support and advice. We are grateful to many reviewers who provided invaluable advice and comments on successive drafts of the paper: We are also immensely grateful to staff at the Danish Ministry of Foreign Affairs who helped to define and direct the project, provided(More)
The bursting K+ channel is the most common channel in fused Torpedo presynaptic nerve terminals. It possesses the property of 'statistical memory', demonstrated by non-random probability of channel opening. We examined the voltage dependence of the statistical memory and report that removal of channel inactivation by hyperpolarization abolishes it. Addition(More)
Synaptic transmission is a key element in neuronal communication in the nervous system. It is determined by two basic sets of processes: release of transmitter from the presynaptic nerve ending and the detection and response by the postsynaptic cell. The release of transmitter is crucially dependent on the interplay among the ion channels in the surface(More)
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