Alexandra L Papaioannou

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CMAJ • NOVEMBER 23, 2010 • 182(17) © 2010 Canadian Medical Association or its licensors 1864 Since the publication of the Osteoporosis Canada guidelines in 2002, there has been a paradigm shift in the prevention and treatment of osteoporosis and fractures. The focus now is on preventing fragility fractures and their negative consequences, rather than on(More)
BACKGROUND Depression and osteoporotic fractures are common ailments among elderly persons. Selective serotonin reuptake inhibitors (SSRIs) are frequently used in the treatment of depression in this population, and the association between daily SSRI use and fragility fractures is unclear. Our objective was to examine the effect of daily SSRI use on the risk(More)
CONTEXT Hip fractures are a public health concern because they are associated with significant morbidity, excess mortality, and the majority of the costs directly attributable to osteoporosis. OBJECTIVE To examine trends in hip fracture rates in Canada. DESIGN, SETTING, AND PATIENTS Ecologic trend study using nationwide hospitalization data for 1985 to(More)
Teriparatide (rDNA origin) injection [recombinant human PTH (1-34)] stimulates bone formation, increases bone mineral density (BMD), and restores bone architecture and integrity. In contrast, bisphosphonates reduce bone resorption and increase BMD. We compared the effects of teriparatide and alendronate sodium on BMD, nonvertebral fracture incidence, and(More)
BACKGROUND Little empirical research has examined the multiple consequences of osteoporosis on quality of life. METHODS Health related quality of life (HRQL) was examined in relationship to incident fractures in 2009 postmenopausal women 50 years and older who were seen in consultation at our tertiary care, university teaching hospital-affiliated office(More)
BACKGROUND STRATIFY is a prediction tool developed for use in for hospital inpatients, using a 0-5 score to predict patients who will fall. It has been widely used as part of hospital fall prevention plans, but it is not clear how good its operational utility is in a variety of settings. OBJECTIVES (i) to describe the predictive validity of STRATIFY for(More)
BACKGROUND Fractures have largely been assessed by their impact on quality of life or health care costs. We conducted this study to evaluate the relation between fractures and mortality. METHODS A total of 7753 randomly selected people (2187 men and 5566 women) aged 50 years and older from across Canada participated in a 5-year observational cohort study.(More)
BACKGROUND The presence of a fragility fracture is a major risk factor for osteoporosis, and should be an indicator for osteoporosis diagnosis and therapy. However, the extent to which patients who fracture are assessed and treated for osteoporosis is not clear. METHODS We performed a review of the literature to identify the practice patterns in the(More)
OBJECTIVE To review the effect of risedronate on bone density and fractures in postmenopausal women. DATA SOURCES We searched MEDLINE from 1966 to the end of 2000 and examined citations of relevant articles and the proceedings of international osteoporosis meetings. STUDY SELECTION We included eight randomized, placebo-controlled trials of(More)
BACKGROUND Vertebral fractures are associated with increased morbidity (e.g., pain, reduced quality of life), and mortality. Therapeutic exercise is a non-pharmacologic conservative treatment that is often recommended for patients with vertebral fractures to reduce pain and restore functional movement. OBJECTIVES Our objectives were to evaluate the(More)