Alexandra Hubenko Baker

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primary challenge in responding to both natural and man-made disasters is communication. This has been highlighted by recent disasters such as the 9/11 terrorist attacks and Hurricane Katrina [2, 5, 6]. A problem frequently cited by responders is the lack of radio interoperability. Responding organizations must work in concert to form a cohesive plan of(More)
Dysregulation of matrix degrading metalloproteinase enzymes (MMPs) leads to increased extracellular matrix turnover, a key event in the local invasion and metastasis of many tumours. The tissue inhibitors of metalloproteinases (TIMPs) limit the activity of MMPs, which suggests their use in gene therapy. We have previously shown that overexpression of(More)
We have used adenovirus-mediated gene delivery of tissue inhibitor of metalloproteinase (TIMP)-1, -2, and -3 to examine their effect on the invasion capacity of metastatic melanoma cell lines SK-Mel-5 and A2058. Infection of melanoma cells with recombinant replication-deficient adenoviruses coding for TIMP-1, TIMP-2, and TIMP-3 resulted in marked secretion(More)
BACKGROUND Elevated serum immunoglobulin (Ig) E is a diagnostic marker of immediate-type allergic reactions. We hypothesize that serum IgE does not necessarily reflect total body IgE because in vivo IgE can be bound to cell surface receptors such as FcepsilonRI and FcepsilonRII (CD23). The aim of this study was to analyze the relationships between levels of(More)
Degradation of the extracellular basement membrane is implicated in atherosclerosis, restenosis after angioplasty, and intimal thickening of vein grafts. Upregulation of metalloproteinase (MMP)-2 and MMP-9 accompanies neointima formation in cholesterol-fed rabbits, in rat and pig models of angioplasty, and in organ cultures of human saphenous veins. MMPs(More)
Clostridium difficile infection (CDI) results in toxin-induced epithelial injury and marked intestinal inflammation. Fecal markers of intestinal inflammation correlate with CDI disease severity, but regulation of the inflammatory response is poorly understood. Previous studies demonstrated that C. difficile toxin TcdA activates p38 kinase in tissue culture(More)
Soluble IgE receptors are potential in vivo modulators of IgE-mediated immune responses and are thus important for our basic understanding of allergic responses. We here characterize a novel soluble version of the IgE-binding alpha-chain of Fc-epsilon-RI (sFcεRI), the high affinity receptor for IgE. sFcεRI immunoprecipitates as a protein of ∼40 kDa and(More)
The purpose of this study is to propose and validate a method to measure the value of situational awareness at the small-unit tactical level. Currently, the Situational Awareness Global Assessment Technique (SAGAT) is widely considered the best method for measuring situational awareness. However, research on situational awareness is largely focused at the(More)
of the feet and(body should he avoided, an(l some patients are helped by a woollen abdominal binder. WVarm baths are useful in relieving spasm. Of drugs, those of the atropine group are of great service, tincture of belladonna or hyoscyamus being commonly employed. One must findl the optimum dose for each case, as individual susceptibility is variable. It(More)
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