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Longitudinal study of leukocyte DNA methylation and biomarkers for cancer risk in older adults
TLDR
Results show that changes in cellular composition explains much of the cross-sectional and longitudinal variation in CpG methylation, and differential methylation and longitudinal dynamics at specific CpGs could provide powerful indicators of cancer development and/or progression.
Longitudinal Study of Leukocyte DNA Methylation and Biomarkers for Cancer Risk in Older Adults
TLDR
Analysis of within-individual change from baseline to Year 6 found significant correlations between the rates of change in methylation in RPTOR, REC8 and ZSWIM5, and time to cancer diagnosis.