Alexandra Goll

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Knowledge about the extent of total variation experienced between samples from different individuals is of great importance for the design of not only proteomics but every clinical study. This variation defines the smallest statistically significant detectable signal difference when comparing two groups of individuals. We isolated platelets from 20 healthy(More)
PURPOSE To examine whether the encouraging functional results one year after photodynamic therapy (PDT) can be maintained up to three years. DESIGN Prospective interventional case series. METHODS Highly myopic eyes that had been treated with PDT for subfoveal choroidal neovascularization and had been observed at least 36 months were included. Distance(More)
BACKGROUND Low-energy extracorporeal shock wave therapy is an alternative treatment, with limited evidence for effectiveness, for calcific tendinitis of the rotator cuff. HYPOTHESIS Objective localization of the calcium deposit by 3-dimensional, computer-assisted navigation reveals superior clinical and radiographic outcomes compared to localization(More)
The optically pure phenylalkylamine Ca2+-antagonist (−)-3H-desmethoxyverapamil has been used to directly label putative Ca2+ channels in thaw-mounted guinea-pig brain sections and in hippocampus homogenates. The autoradiographic distribution of (−)-3H-desmethoxyverapamil binding shows the highest density of binding sites in the molecular layer of the(More)
Four 1,4-dihydropyridine calcium channel blockers [3H]-nifedipine, [3H]-nitrendipine, [3H]-nimodipine and [3H]-PN 200 110 (Isopropyl 4-(2,1,3,benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-5-methoxy-carbonylpyridine-3-carboxylate) were employed to label putative calcium channels in guinea-pig hind limb skeletal muscle membranes. The four radioligands differed(More)
HINTERGRUND: Extrakorporale Stoßwellentherapie ist ein empfohlenes Verfahren in der Behandlung der Tendinitis Calcarea. Navigierte niederenergetische Stoßwellentherapie führt zu signifikant besseren Ergebnissen als eine biofeedback Ortung. Diese Untersuchung wurde geplant um zu prüfen ob das Ergebnis nach navigierter nieder-energetischer Stoßwellentherapie(More)
PURPOSE The aim of this study was to examine whether the presence of retinal angiomatous proliferation (RAP) is a prognostic factor in subretinal surgery with transplantation of a suspension of autologous retinal pigment epithelial (RPE) cells. METHODS Eyes that had been followed for at least 12 months after subretinal surgery were reviewed(More)
This study aimed to assess, using multiple regression analyses, the roles of lower esophageal sphincter, esophageal contractile and transport function, hiatal hernia, age, sex, and body mass for esophageal acid exposure in upright and recumbent postures and for esophagitis. In 116 patients with reflux symptoms, acid exposure was recorded by 24-hr pH(More)
Partially purified plasma membranes were prepared from cat ventricle. The purification factors for the calcium channel ligands (+)-3H-PN 200-110, 3H-nimodipine (1,4-dihydropyridines) and (−)-3-H-desmethoxyverapamil (a phenylalkylamine) were 3.1-, 3.4- and 2.9-fold, respectively, whilst β-adrenoceptors labelled with (−)-3H-dihydroalprenolol were purified(More)