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Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells.

• David A. Zacharias, Jonathan D. Violin, Alexandra C Newton, Roger Tsien
• Science
• 2002

Many proteins associated with the plasma membrane are known to partition into submicroscopic sphingolipid- and cholesterol-rich domains called lipid rafts, but the determinants dictating this… (More)

Specificity and Stability in Topology of Protein Networks

• Jonathan D. Violin, Alexandra C Newton, Roger Tsien

PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth.

• Tianyan Gao, Frank B Furnari, Alexandra C Newton
• Molecular cell
• 2005

Akt/protein kinase B critically regulates the balance between cell survival and apoptosis. Phosphorylation of Akt at two key sites, the activation loop and the hydrophobic motif, activates the kinase… (More)

PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms.

• John Brognard, Emma Sierecki, Tianyan Gao, Alexandra C Newton
• Molecular cell
• 2007

Akt/protein kinase B controls cell growth, proliferation, and survival. We recently discovered a novel phosphatase PHLPP, for PH domain leucine-rich repeat protein phosphatase, which terminates Akt… (More)

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C.

• Valeria Facchinetti, Weiming Ouyang, +12 authors Estela Jacinto
• The EMBO journal
• 2008

The target of rapamycin (TOR), as part of the rapamycin-sensitive TOR complex 1 (TORC1), regulates various aspects of protein synthesis. Whether TOR functions in this process as part of TORC2 remains… (More)

A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C

• Jonathan D. Violin, Jin Zhang, Roger Tsien, Alexandra C Newton
• The Journal of cell biology
• 2003

Signals transduced by kinases depend on the extent and duration of substrate phosphorylation. We generated genetically encoded fluorescent reporters for PKC activity that reversibly respond to… (More)

Cellular Signaling Pivoting around PDK-1

• A. C. Toker, Alexandra C Newton
• Cell
• 2000

the discovery that PDK-1 is the Akt/PKB upstream ki-Harvard Medical School nase came the observation that PDK-1 also phosphory-Boston, Massachusetts 02215 lates a number of other kinases, including… (More)

The phosphatase PHLPP controls the cellular levels of protein kinase C.

• Tianyan Gao, John Brognard, Alexandra C Newton
• The Journal of biological chemistry
• 2008

The life cycle of protein kinase C (PKC) is controlled by multiple phosphorylation and dephosphorylation steps. The maturation of PKC requires three ordered phosphorylations, one at the activation… (More)

The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail.

• Christine M. Gould, Natarajan Kannan, Susan S. Taylor, Alexandra C Newton
• The Journal of biological chemistry
• 2009

The life cycle of protein kinase C (PKC) is tightly controlled by mechanisms that mature the enzyme, sustain the activation-competent enzyme, and degrade the enzyme. Here we show that a conserved… (More)

Regulation of protein kinase C ζ by PI 3-kinase and PDK-1

• Margaret M. Chou, Weimin Hou, +6 authors A. C. Toker
• Current Biology
• 1998

BACKGROUND Protein kinase C zeta (PKC zeta) is a member of the PKC family of enzymes and is involved in a wide range of physiological processes including mitogenesis, protein synthesis, cell survival… (More)

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