Learn More
BACKGROUND & AIMS Interactions between genetic and environmental factors are believed to be involved in onset and initiation of inflammatory bowel disease. We analyzed the interaction between gastrointestinal mucosal microbiota and host genes in twin pairs discordant for ulcerative colitis (UC) to study the functional interaction between microbiota and(More)
BACKGROUND Genetic predisposition as a cause of inflammatory bowel disease (IBD) has been proven by both family and twin studies and genetic variants associated with the disease have been identified. The aim of our study was to determine the concordance rates for IBD in German twin pairs and to evaluate clinical characteristics of concordant and discordant(More)
The colonic mucosa-associated flora (MAF) in patients with active ulcerative colitis (UC) (n = 13) was investigated by examining 16S rRNA gene signatures during remission and relapse against levels for controls (n = 5). Baseline reduction, temporal instability, and decrease of bacterial richness toward relapse were observed for UC patients, whereas the MAF(More)
Algorithm for decomposition of differences between aggregate demographic measures and its application to life expec-tancies, healthy life expectancies, parity-progression ratios and total fertility rates. 1 Introduction 500 2 Decomposition of differences between two life expectancies and between two healthy life expectancies 501 2.1 Life expectancies 501(More)
1 Introduction 306 2 Definitions and properties 308 2.1 The Lorenz curve 308 2.2 Application to the distribution of length of life 308 2.3 Gini coefficient 310 2.4 Basic properties of inequality measures 313 3 Empirical trends in Gini coefficient and other measures of inequality and judgements about direction of changes in inequality 314 4 Computation of(More)
Phenotypic variation between individuals, such as different mRNA expression levels, is influenced by genetic and nongenetic factors. Although several studies have addressed the interplay between genotypes and expression profiles in various model organisms in the recent years, the detailed and relative contributions of genetic and nongenetic factors in(More)
INTRODUCTION Environmental factors may play an important role in the pathogenesis of IBD. The history of patients of the German IBD twin study was analyzed by questionnaires and interviews. METHODS Randomly selected German monozygotic (MZ) and dizygotic (DZ) twins with at least one sibling suffering from IBD (n=512) were characterized in detail including(More)
Previous longevity studies of related individuals such as twins or siblings based on the major gene model have shown that the frequency and the relative risk of mortality of a beneficial allele in the population could be estimated. If, in addition to survival data for related individuals, the genetic markers data are available, one could try to locate the(More)
  • 1