Alexander Yu. Mitrophanov

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Feedback loops have been identified in a variety of regulatory systems and organisms. While feedback loops of the same type (negative or positive) tend to have properties in common, they can play distinctively diverse roles in different regulatory systems, where they can affect virulence in a pathogenic bacterium, maturation patterns of vertebrate oocytes(More)
One of the major goals of computational sequence analysis is to find sequence similarities, which could serve as evidence of structural and functional conservation, as well as of evolutionary relations among the sequences. Since the degree of similarity is usually assessed by the sequence alignment score, it is necessary to know if a score is high enough to(More)
The TKF91 model of biological sequence evolution describes changes in the sequence length via an infinite state-space birth-death process, which we term the TKF91-BD process. The TKF91 model assumes that, for any pair of modern sequences, the ancestral sequence has equilibrium length distribution, an assumption whose validity has not been rigorously(More)
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