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5-HT7R/G12 signaling regulates neuronal morphology and function in an age-dependent manner.

• Fritz Kobe, Daria Guseva, +16 authors Evgeni Ponimaskin
• The Journal of neuroscience : the official…
• 2012

The common neurotransmitter serotonin controls different aspects of early neuronal differentiation, although the underlying mechanisms are poorly understood. Here we report that activation of the… (More)

How serotonin receptors regulate morphogenic signalling in neurons

• Alexander Wirth, Katrin Holst, Evgeni Ponimaskin
• Progress in Neurobiology
• 2017

Serotonin (5-hydroxytrympamine or 5-HT) is one of the phylogenetically oldest neurotransmitters, and the serotonergic system is among the earliest developed neuronal systems. Serotonin is critically… (More)

Cdc42: an important regulator of neuronal morphology.

• Chen Chen, Alexander Wirth, Evgeni Ponimaskin
• The international journal of biochemistry & cell…
• 2012

Regulation of neuronal morphology and activity-dependent synaptic modifications involves reorganization of the actin cytoskeleton. Dynamic changes of the actin cytoskeleton in many cell types are… (More)

Computational and experimental analysis of the transmembrane domain 4/5 dimerization interface of the serotonin 5-HT(1A) receptor.

• Nataliya Gorinski, Noga Kowalsman, +6 authors Masha Y. Niv
• Molecular pharmacology
• 2012

Experimental evidence suggests that most members of class A G-protein coupled receptors (GPCRs) can form homomers and heteromers in addition to functioning as single monomers. In particular,… (More)

Cellular mechanisms of the 5-HT7 receptor-mediated signaling

• Daria Guseva, Alexander Wirth, Evgeni Ponimaskin
• Front. Behav. Neurosci.
• 2014

Serotonin (5-hydroxytryptamine or 5-HT) is an important neurotransmitter regulating a wide range of physiological and pathological functions via activation of heterogeneously expressed 5-HT… (More)

Dual lipidation of the brain-specific Cdc42 isoform regulates its functional properties.

• Alexander Wirth, Chen Chen-Wacker, +4 authors Evgeni Ponimaskin
• The Biochemical journal
• 2013

Cdc42 (cell division cycle 42) is a member of the Rho GTPase family which regulates a variety of cellular activities by controlling actin cytoskeleton and gene expression. Cdc42 is expressed in the… (More)

Development / Plasticity / Repair 5-HT 7 R / G 12 Signaling Regulates Neuronal Morphology and Function in an Age-Dependent Manner

• Fritz Kobe, Daria Guseva, +16 authors Evgeni Ponimaskin
• 2012

Fritz Kobe,1,2* Daria Guseva,3* Thomas P. Jensen,4* Alexander Wirth,3 Ute Renner,1,2 Dietmar Hess,1,2 Michael Müller,1,2 Lucian Medrihan,1,2 Weiqi Zhang,1,5 Mingyue Zhang,5 Katharina Braun,6 Sören… (More)

Palmitoylation of cdc42 Promotes Spine Stabilization and Rescues Spine Density Deficit in a Mouse Model of 22q11.2 Deletion Syndrome.

• Enora Moutin, Irina Nikonenko, +4 authors Dominique Muller
• Cerebral cortex
• 2017

22q11.2 deletion syndrome (22q11DS) is associated with learning and cognitive dysfunctions and a high risk of developing schizophrenia. It has become increasingly clear that dendritic spine… (More)

The effect of experimental balancing interferences on masticatory performance.

• Lydia Eberhard, Sebastian Till Braun, Alexander Wirth, H J Schindler, Daniel Hellmann, N N Giannakopoulos
• Journal of oral rehabilitation
• 2014

Immediate adaptation to experimental-balancing interferences is known to affect jaw kinematics and electromyographic activity (EMG). However, little is known about the influence on masticatory… (More)

Experimental and finite element analysis of the mouse caudal vertebrae loading model: prediction of cortical and trabecular bone adaptation.

• Duncan James Webster, Alexander Wirth, G Harry van Lenthe, Ralph Müller
• Biomechanics and modeling in mechanobiology
• 2012

In this study, we attempt to predict cortical and trabecular bone adaptation in the mouse caudal vertebrae loading model using knowledge of bone's local mechanical environment at the onset of… (More)

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