Learn More
BACKGROUND Inflammatory bowel disease is associated with a higher risk for venous thromboembolism (VTE). Whether Clostridium difficile infection similarly increases this risk is unknown. METHODS This was a retrospective analysis of patients admitted to the surgical intensive care unit (ICU) at the Cedars-Sinai Medical Center from February 2011 to July(More)
INTRODUCTION Splenectomy is associated with a life-long risk for overwhelming infections. The risk for early post-operative infectious complications following traumatic and elective splenectomy is, however, understudied. This investigation aimed to determine if splenectomy increases the risk for post-operative infections. METHODS This was a retrospective(More)
BACKGROUND The purpose of the current study was to investigate the effect of early adrenergic hyperactivity as manifested by prehospital (emergency medical service [EMS]) hypertension on outcomes of traumatic brain injury (TBI) patients and to develop a prognostic model of the presence of TBI based on EMS and admission (emergency department [ED])(More)
Traumatic brain injury (TBI) is an enormous public health problem, with 1.7 million new cases of TBI recorded annually by the Centers for Disease Control. However, TBI has proven to be an extremely challenging condition to treat. Here, we apply a nanoprodrug strategy in a mouse model of TBI. The novel nanoprodrug contains a derivative of the nonsteroidal(More)
which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Alerts: Sign up at eneuro.org/alerts to receive customized email alerts when the fully formatted version of this article is published. Acute traumatic brain injury does not exacerbate ALS in the SOD1G93A rat model This is a(More)
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease in which upper and lower motor neurons degenerate, leading to muscle atrophy, paralysis, and death within 3 to 5 years of onset. While a small percentage of ALS cases are genetically linked, the majority are sporadic with unknown origin. Currently, etiological links are associated with(More)
ii DEDICATION This work is dedicated to my mother and father who provided me with love and support unconditionally throughout my life. And to my son, whenever you may be. iii ACKNOWLEDGEMENTS I would like to acknowledge my advisor Dr. Christopher Eamon for all of his guidance and effort on this dissertation and for his support throughout the process. I(More)
  • 1