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SNARE complexes form between the synaptic vesicle protein synaptobrevin and the plasma membrane proteins syntaxin and SNAP25 to drive membrane fusion. A cytosolic protein, complexin (Cpx), binds to the SNARE bundle, and its accessory helix (AH) functions to clamp synaptic vesicle fusion. We performed molecular-dynamics simulations of the SNARE/Cpx complex… (More)
The core of a game is defined as the set of outcomes acceptable for all coalitions. This is probably the simplest and most natural concept of cooperative game theory. However, the core can be empty because there are too many coalitions. Yet, some players may not like or know each other, so they cannot form a coalition. The following generalization seems… (More)
Patterned depolarization of Drosophila motor neurons can rapidly induce the outgrowth of new synaptic boutons at the larval neuromuscular junction (NMJ), providing a model system to investigate mechanisms underlying acute structural plasticity. Correlative light and electron microscopy analysis revealed that new boutons typically form near the edge of… (More)
Synaptic transmission is dynamic, plastic, and highly regulated. Drosophila is an advantageous model system for genetic and molecular studies of presynaptic and postsynaptic mechanisms and plasticity. Electrical recordings of synaptic responses represent a wide-spread approach to study neuronal signaling and synaptic transmission. We discuss experimental… (More)
The basic results obtained by the author in the theory of supercavities in compressible fluid have been presented. The modern numerical methods have been applied in this investigation and the basic correlations for shock in water have been considered. The characteristic features of supersonic cavitation flows and their difference from the analogous flows in… (More)
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The core of a game is deened as the set of outcomes acceptable for all coalitions. This is probably the simplest and most natural concept of cooperative game theory. However, the core can be empty because there are too many coalitions. Yet, some players may not like or know each other, so they cannot form a coalition. Let K be a xed family of coalitions.… (More)