The goal of the Complex Trait Consortium is to promote the development of resources that can be used to understand, treat and ultimately prevent pervasive human diseases. Existing and proposed mouse… (More)
This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that… (More)
Micropopulations consisting of six male mice of different genotypes were studied (each of lines A/He, CBA/Lac, C57BL/6J, DD, YT, and PT was represented by one male). Interlinear differences in the… (More)
Four activities of key microsomal steroidogenic enzymes (3 beta-hydroxysteroid dehydrogenase-isomerase, microsomal cytochrome P45017 beta, and 17-ketosteroid reductase) were compared in Leydig cells… (More)
Comparative genetic study of the basal plasma testosterone level, relative weights of testicles, seminal vesicles, and preputial glands in 13 strains of laboratory mice showed significant interstrain… (More)
Strain-specific differences in the production of spermatozoa and incidence of atypical spermatogenesis were studied in males of 7 inbred strains: BALB/cLac, PT, CBA/Lac, DD, A/ He, C57Bl/6J, and YT.… (More)
Using gel retardation of DNA samples and specific antibodies, binding sites for the transcription factor SF-1 were found in positions −53/−44-and −285/−270 in the promoter region of the mouse Cyp17… (More)
We have studied the role of the adrenergic and dopaminergic mechanisms in the activation of the endocrine testicular function of CBA/Lac and A/He male mice induced by the presence of a female in… (More)