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A comparative analysis of the physiological actions of native angiotensin I and angiotensin II and protein-peptide complexes of angiotensin I and angiotensin II on drinking behavior in rats was performed. The protein-peptide complexes of angiotensin I and angiotensin II had wider spectra of physiological activity than the native peptides. Protein-conjugated(More)
The abundance of fat tissue surrounding normal and malignant epithelial mammary cells raises the questions whether such "adipose milieu" is important in the local proinflammatory/genotoxic shift, which apparently promotes tumor development and worsens prognosis, and what conditions stimulate this shift, or "adipogenotoxicosis." We studied 95 mammary fat(More)
The results show that during long-term immunization of rats against conjugates of angiotensin II with bovine serum albumin definite age dynamics of immune response have been observed. It was shown that the changes of physiological readings were correlated with growing of antibodies titer against angiotensin II, accordingly, as the immune response was lower,(More)
In experiments on rabbits, instrumental and complex conditioned alimentary behaviour was studied at various ways of raising alimentary motivation to extreme levels. Animals behaviour in these conditions could acquire an outwardly non-motivated (in relation to alimentary need) character. It is suggested that these phenomena are based on the transformation of(More)
The aim of this study is to investigate time-related changes in substance P (SP), beta-endorphin (BE), and corticosterone (CORT) levels due to DSIP aftereffects in the control and stress rats. Experiments were carried out on male Wistar and August rats. The SP and BE immunoreactivity in the hypothalamus and plasma samples was determined(More)
Food motivation in rabbits injected intravenously with beta-lipotropin (3-5 microliters, 91.5 X 10(-6) mumole/ml, in a physiological saline) was studied in different stages of food motivation excitation. It was found that the effect of beta-lipotropin depended on initial motivation of the animals. In hungry rabbits, beta-lipotropin primarily inhibited(More)
Angiotensin-converting enzyme (ACE) activity in serum and some brain areas, level of angiotensin I in the blood and drinking behaviour during immunization of rats against conjugate of angiotensin II with bovine serum albumin (BSA) were studied. The results show that an increase in antibodies against angiotensin II was correlated with elevated ACE activity(More)
Central mechanisms of angiotensin involvement in initiation and realization of operant forms of drinking behavior were investigated. It was suggested that intracerebroventricular microinjection of angiotensin-II and angiotensin-IIl specifically affected the learned forms of drinking behavior. The experiments demonstrated that [des-Asp1]-angiotensin-I(More)
Chemical sensitivity to acetylcholine (Ach) and angiotensin II (A-II) of the neurons from the perifornical area of the posterio-lateral hypothalamus was studied in rats after 30 days of alcoholization with 20% ethanol solution instead of water. The artificially formed alcohol motivation was accompanied by profound changes of the neuronal sensitivity to Ach(More)
The considerable individual variability of changes in physiological functions under identical conditions of emotional stress has necessitated the study of the neurochemical mechanisms of resistance of organisms [4]. Research into the possible connection of central regulation of physiological functions during stress with the individual features of animals,(More)