Alexander V Kotov

Learn More
The abundance of fat tissue surrounding normal and malignant epithelial mammary cells raises the questions whether such "adipose milieu" is important in the local proinflammatory/genotoxic shift, which apparently promotes tumor development and worsens prognosis, and what conditions stimulate this shift, or "adipogenotoxicosis." We studied 95 mammary fat(More)
Chemical sensitivity to acetylcholine (Ach) and angiotensin II (A-II) of the neurons from the perifornical area of the posterio-lateral hypothalamus was studied in rats after 30 days of alcoholization with 20% ethanol solution instead of water. The artificially formed alcohol motivation was accompanied by profound changes of the neuronal sensitivity to Ach(More)
Central mechanisms of angiotensin involvement in initiation and realization of operant forms of drinking behavior were investigated. It was suggested that intracerebroventricular microinjection of angiotensin-II and angiotensin-IIl specifically affected the learned forms of drinking behavior. The experiments demonstrated that [des-Asp1]-angiotensin-I(More)
We compared activity of synthetic complexes of angiotensin II and functionally different proteins (transport protein, serum albumin and neurospecific Ca2+-binding protein S100b) as analogues of endogenous protein-peptide complexes. Physiological activity of angiotensin II was specifically modified by these proteins. It was hypothesized that the complex of(More)
A comparative analysis of the physiological actions of native angiotensin I and angiotensin II and protein-peptide complexes of angiotensin I and angiotensin II on drinking behavior in rats was performed. The protein-peptide complexes of angiotensin I and angiotensin II had wider spectra of physiological activity than the native peptides. Protein-conjugated(More)
Immobilization stress induced catecholamines level changes were studied in brain nuclei, taking part in blood pressure central regulation in rats with different zoosocial position. The significant differences in catecholamines level between the zoosocial groups of rats were shown in dopamine synthesized hypothalamic nuclei-n. arcuatus, n. periventricularis(More)