Alexander S Tiganov

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Bipolar disorder (BD) is a common and highly heritable mental illness and genome-wide association studies (GWAS) have robustly identified the first common genetic variants involved in disease aetiology. The data also provide strong evidence for the presence of multiple additional risk loci, each contributing a relatively small effect to BD susceptibility.(More)
We conducted a genome-wide association study (GWAS) and a follow-up study of bipolar disorder (BD), a common neuropsychiatric disorder. In the GWAS, we investigated 499,494 autosomal and 12,484 X-chromosomal SNPs in 682 patients with BD and in 1300 controls. In the first follow-up step, we tested the most significant 48 SNPs in 1729 patients with BD and in(More)
Two recent studies reported evidence for association between genetic variation of the positional candidate gene P2RX7 on chromosome 12q24 and bipolar I disorder (BPI) [Barden et al. (2006); Am J Med Genet Part B 141B:374-382; McQuillin et al. (2008); Mol Psychiatry 13:1-7] and one study found association with unipolar major depression (Mdd-UP) [Lucae et al.(More)
Bipolar disorder (BD) is a severe and highly heritable neuropsychiatric disorder with a lifetime prevalence of 1%. Molecular genetic studies have identified the first BD susceptibility genes. However, the disease pathways remain largely unknown. Accumulating evidence suggests that microRNAs, a class of small noncoding RNAs, contribute to basic mechanisms(More)
Bipolar disorder (BD) is a highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. BD shows substantial clinical and genetic overlap with other psychiatric disorders, in particular schizophrenia (SCZ). The genes underlying this etiological overlap remain largely unknown. A recent SCZ genome wide association(More)
  • A S Tiganov
  • Vestnik Rossiiskoi akademii meditsinskikh nauk
  • 2011
A classification of endogenous affective disorders based on clinical manifestations of a concrete disease is proposed. It reflects one of the stages of investigations into the structure of psychopathological manifestations of depressive and maniacal disorders. Further studies may provide data for the adjustment of the classification to the current(More)
Analysis of EEG spectral power values and quantitative clinical scores of depressive conditions has been carried out in the dynamics of the treatment of 40 patients with endogenous depression, with the main goal to study the neurophysiological correlates and to search for possible predictors of therapeutic outcome. The reduction of depressive symptoms by(More)
  • A S Tiganov
  • Zhurnal nevrologii i psikhiatrii imeni S.S…
  • 1996
Both international (ICD-9, ICD-10) and national classifications were used as the examples for establishing the connection between the methodology of diagnosis and creation of systematics of mental diseases. The thesis was formulated that the creation of the national classification well grounded scientifically is to reflect main traditions and tendencies of(More)
  • A S Tiganov
  • Zhurnal nevrologii i psikhiatrii imeni S.S…
  • 2013
The significant variety of psychopathological presentations of depression causes difficulties in its diagnosis. Depression of middle age is subdivided depending on the predomination of one or another disorder in the clinical picture. There are simple depression and complicated depression with additional psychopathological symptoms. The most difficult is to(More)