Alexander S. Maltsev

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N-Terminal acetylation of α-synuclein (aS), a protein implicated in the etiology of Parkinson's disease, is common in mammals. The impact of this modification on the protein's structure and dynamics in free solution and on its membrane binding properties has been evaluated by high-resolution nuclear magnetic resonance and circular dichroism (CD)(More)
The antibiotic squalamine forms a lyotropic liquid crystal at very low concentrations in water (0.3-3.5% w/v), which remains stable over a wide range of temperature (1-40 °C) and pH (4-8). Squalamine is positively charged, and comparison of the alignment of ubiquitin relative to 36 previously reported alignment conditions shows that it differs substantially(More)
α-Synuclein (αS) is an intrinsically disordered protein that is water-soluble but also can bind negatively charged lipid membranes while adopting an α-helical conformation. Membrane affinity is increased by post-translational N-terminal acetylation, a common modification in all eukaryotic cells. In the presence of lipid vesicles containing a small fraction(More)
We investigated effect of aldehydic products of lipid peroxidation, malondialdehyde (MDA) and 4-hydroxynonenal (HNE) on prostaglandin (PG) E2 receptors of liver plasma membranes. The modification of the membranes by MDA diminished PGE2 binding, decreasing receptor affinity for PGE2 and receptor density whereas HNE increased PGE2 binding, enhanced receptor(More)
An evaluation of phenotype features of house mice populations in the city of Ishim is carried out. In populations studied, the morphological features inherent to both Mus musculus and Mus domesticus are found. Reproduction parameters of different populations in laboratory breeding and results of laboratory crosses between different populations of M.(More)
The degree of development of the mechanisms of postcopulatory isolation was evaluated on the basis of experimental hybridization of representatives of three subspecies of M. musculus (M. m. musculus, M. m. wagneri, and M. m. gansuensis) and remote populations of the subspecies M. m. musculus. Experimental crosses between the different subspecies and(More)
Analysis of the control region of mitochondrial DNA (mtDNA) or D-loop of 96 house mice (Mus musculus) from Russia, Moldova, Armenia, Azerbaijan, Kazakhstan, and Turkmenistan has been used to reconstruct the phylogenetic relationships and phylogeographic patterns of intraspecific forms. New data on the phylogenetic structure of the house mouse are presented.(More)
The role of invasions in formation of the phylogeographic structure of a synanthropic species of house mouse (Mus musculus) is investigated. The probable ways of its expansion in some areas of Russia and the near abroad are analyzed. The genetic variability of subspecies and populations of M. musculus is evaluated by the data on polymorphism of the(More)
Chemical communication is one of the most important branches of zoology and chemical ecology. In the review, we analyze the main directions of chemical communication in mammals, mainly as based on the works of Russian researchers belonging to the school of the late Academician V.E. Sokolov, some approaches to solving specific zoological and ecological(More)
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