Alexander S Ioannidis

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BACKGROUND Fabry's disease is an X-linked lysosomal storage disorder characterised by deficient activity of the enzyme alpha-galactosidase A. AIM To study eye abnormalities in patients with Fabry's disease in the Fabry Outcome Survey (FOS). METHODS This is the largest study of ocular manifestations in patients with Fabry's disease. In all, 173 of the(More)
PURPOSE OF REVIEW To report the most recent developments in the diagnosis and management of cyclodialysis clefts. RECENT FINDINGS Cyclodialysis clefts are rare. The most common reason for presentation is blunt-ocular trauma followed by various iatrogenic interventions. Diagnosis is particularly challenging and various new noninvasive techniques have been(More)
PURPOSE To investigate factors that may influence successful correction of hypotony in a consecutive series of patients with cyclodialysis clefts repaired surgically over a 10-year period. DESIGN Retrospective interventional case series. METHODS Interventional case series of consecutive patients with cyclodialysis clefts and hypotony treated surgically(More)
AIMS This study surveys the current use of investigations for the management of glaucoma in hospital practice by UK ophthalmologists. METHODS A total of 1007 questionnaires were posted to all active NHS consultant ophthalmologists. They were asked to indicate the type of hospital (whether university (UTH) or general (DGH) hospital), glaucoma specialist(More)
PURPOSE Fabry Disease (FD) is a rare X-linked metabolic disorder characterized by diffuse deposition of sphingolipids in many tissues. Retinal vessel tortuosity is a common ocular manifestation in FD and may represent a useful marker for the disease. Unfortunately its clinical evaluation is poorly reproducibile and alternative means of evaluation may be of(More)
PURPOSE To present a case of traumatic dislocation of an Ophtec Artisan phakic intraocular lens (PIOL) and an analysis of the endothelial cell count. METHODS The patient presented with blurred vision in his left eye after sustaining a brow laceration. History included uncomplicated bilateral implantation of an Artisan PIOL to correct myopia. RESULTS The(More)
PURPOSE To report a case of unilateral keratoconus in a 7- year-old female, secondary to chronic persistent eye-rubbing in the absence of any systemic condition. DESIGN Observational case report. METHODS In the case of this child, no organic cause was found to explain the onset of keratoconus other than persistent eye-rubbing in the affected eye. (More)
PURPOSE To present a case of a child with an extensive facial hemangioma in whom the suspicion of intracranial involvement was raised by visual evoked potential (VEP) evaluation. DESIGN Observational case report. METHODS VEP analysis was performed using flash and pattern stimuli to determine whether treatment intervention other than occlusion therapy(More)
A 49-year-old man with AIDS developed acute monocular visual loss and an ipsilateral swollen optic disc with a large right relative afferent pupillary defect, a nerve fiber bundle visual field defect, and a peripapillary retinal infiltrate. Lumbar puncture disclosed cytomegalovirus (CMV) DNA on polymerase chain reaction (PCR). Treatment with oral(More)