Alexander R. Rutherford

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BACKGROUND Expanding access to highly active antiretroviral therapy (HAART) has become an important approach to HIV prevention in recent years. Previous studies suggest that concomitant changes in risk behaviours may either help or hinder programs that use a Treatment as Prevention strategy. ANALYSIS We consider HIV-related risk behaviour as a social(More)
Realizing the full individual and population-wide benefits of antiretroviral therapy for human immunodeficiency virus (HIV) infection requires an efficient mechanism of HIV-related health service delivery. We developed a system dynamics model of the continuum of HIV care in Vancouver, Canada, which reflects key activities and decisions in the delivery of(More)
Creating individualized within-host multiple phase disease models of HIV-1 infection has long been a goal of mathematicians and biologists. The challenge is in trying to build models that are representative of the disease, include realistic parameter estimates, and are able to incorporate a changing model structure. In this paper, we propose a fitting(More)
Injection drug users (IDU) who share needles are at high risk for contracting human immunodeficiency virus (HIV) infection. Social and behavioral influences that promote needle sharing can, therefore, impact HIV transmission. HIV spreads rapidly in IDU communities and interventions that target needle-sharing have had variable results. We constructed a(More)
HIV remains a serious public health problem in many marginalized communities. We develop a network model of the HIV epidemic affecting injection drug users and female sex workers in the Downtown Eastside neighborhood of Vancouver, Canada, calibrated using data from public health surveillance and cohort studies. Many HIV positive individuals are unaware of(More)
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