Alexander R Moise

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BACKGROUND Leber congenital amaurosis (LCA), a heterogeneous early-onset retinal dystrophy, accounts for approximately 15% of inherited congenital blindness. One cause of LCA is loss of the enzyme lecithin:retinol acyl transferase (LRAT), which is required for regeneration of the visual photopigment in the retina. METHODS AND FINDINGS An animal model of(More)
TACI (transmembrane activator and calcium modulator and cyclophilin ligand [CAML] interactor) is a part of a novel network of ligands and receptors involved in B-cell survival and isotype switching. The TACI protein mediates its effects through CAML, an endoplasmic reticulum (ER)-localized protein that controls Ca(2+) efflux. The adenovirus E3-6.7K protein(More)
Competing Interests: WWH and the University of Florida own equity in a company, Applied Genetic Technologies Corporation, that may commercialize some of the technology described in this work. KP owns shares of the company Retinagenix. The University of Washington and Retinagenix may commercialize some of the technology described in this work.(More)
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