Domain specific programming languages tend to be rigid in capability and dependent on either a graphical interface or a scripting language. We present a question-oriented approach that requires no prior knowledge of programming and can be easily adapted to a wide range of domains. Interrogative programming works by "parsing" the user's intent using the… (More)
During mouse sex determination, transient expression of the Y-linked gene Sry up-regulates its direct target gene Sox9, via a 3.2 kb testis specific enhancer of Sox9 (TES), which includes a core 1.4 kb element, TESCO. SOX9 activity leads to differentiation of Sertoli cells, rather than granulosa cells from the bipotential supporting cell precursor lineage.… (More)
Although several efforts have applied search-based approaches to the generation of unit tests, none have demonstrated that these approaches scale beyond small programs. Our experiment compares the ability of three general-purpose AI planners to generate unit tests for Java classes with varying sizes and semantics. Although the GraphPlan planner handled most… (More)
[This corrects the article DOI: 10.1371/journal.pgen.1006520.].
In most eutherian mammals, sex determination is governed by the Y-linked gene Sry, but in African pygmy mice Mus minutoides, Sry action is overridden by a variant X chromosome (X*), yielding X*Y females. We hypothesized that X*Y sex reversal may be underpinned not only by neomorphic X chromosome functionality, but also by a compromised Sry pathway. Here, we… (More)
The Y-chromosomal gene SRY acts as the primary trigger for male sex determination in mammalian embryos. Correct regulation of SRY is critical: aberrant timing or level of Sry expression is known to disrupt testis development in mice and we hypothesize that mutations that affect regulation of human SRY may account for some of the many cases of XY gonadal… (More)
Temporal events are typically visualized on a time line indicating the date they occurred. This perspective is useful when the questions one wishes to answer are related to the date of occurrence. This view, however, makes it difficult to identify patterns related to the relative duration between events or the sequential order. We demonstrate how the simple… (More)