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Antiprotozoal activities of heterocyclic-substituted xanthones from the marine-derived fungus Chaetomium sp.
Investigations of the marine-derived fungus Chaetomium sp. led to the isolation of the new natural products chaetoxanthones A, B, and C (1-3). Compounds 1 and 2 are substituted with a…
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Epoxyphomalin A and B, prenylated polyketides with potent cytotoxicity from the marine-derived fungus Phoma sp.
TLDR
Epoxyphomalin A showed superior cytotoxicity at nanomolar concentrations toward 12 of a panel of 36 human tumor cell lines, and in COMPARE analyses, the observed cytotoxic selectivity pattern of 1 did not correlate with those of reference anticancer agents with known mechanisms of action.
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Monodictyochromes A and B, dimeric xanthone derivatives from the marine algicolous fungus Monodictys putredinis.
TLDR
Investigations of the marine-derived fungus Monodictys putredinis led to the isolation of two novel dimeric chromanones that consist of two uniquely modified xanthone-derived units that were examined for their cancer chemopreventive potential and shown to inhibit cytochrome P450 1A activity.
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Aromatic polyketides from marine algicolous fungi.
TLDR
The investigation of the marine-derived fungi Acremonium and Nodulisporium led to the isolation of the new natural products acremonisol A and (3 R)-7-hydroxy-5-methylmellein, which are biosynthetically related by both being aromatic pentaketides belonging to the dihydroisocoumarins.
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Noduliprevenone: a novel heterodimeric chromanone with cancer chemopreventive potential.
TLDR
The aim of cancer chemopreventive strategy can include the inhibition of phase I enzymes accompanied with an increased phase II metabolism, which inactivates carcinogens and accelerates their renal or biliar elimination.
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Fungal metabolites: structural diversity as incentive for anticancer drug development
TLDR
An overview on the role of natural products in cancer therapy is given and some of the latest results of the group in this area are summarized.
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Epoxyphomalin A (I) and B (II), Prenylated Polyketides with Potent Cytotoxicity from the Marine-Derived Fungus Phoma sp.
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Aromatic Polyketides from the Marine Algicolous Fungus Nodulisporium sp
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