Alexander Pontius

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Stefan Kehraus8
Gabriele M. König8
Gordon M Cragg7
David J Newman7
Anja Krick7
20Nai-Yun Ji
20Bin-Gui Wang
7Stefan Kehraus
7Gabriele M. König
6Anja Krick

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2008
2010
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Antiprotozoal activities of heterocyclic-substituted xanthones from the marine-derived fungus Chaetomium sp.
Investigations of the marine-derived fungus Chaetomium sp. led to the isolation of the new natural products chaetoxanthones A, B, and C (1-3). Compounds 1 and 2 are substituted with a dioxane/tetrahydropyran moiety rarely found in natural products. Compound 3 was identified as a chlorinated xanthone substituted with a tetrahydropyran ring. The… (More)
Monodictyochromes A and B, dimeric xanthone derivatives from the marine algicolous fungus Monodictys putredinis.
Investigations of the marine-derived fungus Monodictys putredinis led to the isolation of two novel dimeric chromanones (1, 2) that consist of two uniquely modified xanthone-derived units. The structures were elucidated by extensive spectroscopic measurements including NOE experiments and CD analysis to deduce the configuration. The compounds (1, 2) were… (More)
Aromatic polyketides from marine algicolous fungi.
The investigation of the marine-derived fungi Acremonium sp. and Nodulisporium sp. led to the isolation of the new natural products acremonisol A ( 1) and (3 R)-7-hydroxy-5-methylmellein ( 2). Both fungi are endophytes of marine algae. Compounds 1 and 2 are biosynthetically related by both being aromatic pentaketides belonging to the dihydroisocoumarins.… (More)
Noduliprevenone: a novel heterodimeric chromanone with cancer chemopreventive potential.
Chemoprevention is considered a new strategy in fighting diverse types of cancer. To influence cancer development and progression, signaling pathways, [1] for example, enzymes like cyclooxygenase-2, [2] transcription factors like NF-kB, [3] and several metabolic processes leading to activation or de-activation of carcinogenic agents, are envisaged as… (More)
Epoxyphomalin A and B, prenylated polyketides with potent cytotoxicity from the marine-derived fungus Phoma sp.
Chemical investigation of a strain of the marine-derived fungus Phoma sp. has led to the discovery of epoxyphomalin A (1) and B (2), two new prenylated polyketides with unusual structural features. Epoxyphomalin A (1) showed superior cytotoxicity at nanomolar concentrations toward 12 of a panel of 36 human tumor cell lines. In COMPARE analyses, the observed… (More)
Fungal metabolites: structural diversity as incentive for anticancer drug development
Natural products play an important role in the development of anticancer drugs. To date, predominantly metabolites from plants and bacteria served as lead structures for anticancer agents. Fungal metabolites and derivatives thereof are much less investigated for their potential in cancer therapy. There are, however, some promising candidates derived from… (More)
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