Alexander  Polevshchikov

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The work deals with analysis of changes of cellular defense factors in the starfish Asterias rubens in response to injection of human erythrocytes (HE). The number of circulating coelomocytes, dynamics of their production of active oxygen forms, activity of peroxidase, and dynamics of elimination of human hemoglobin from coelomic fluid were estimated before(More)
The effect of C-reactive protein (CRP) on the adhesive and biocidal activity (AA and BA) of human neutrophils (HN) in vitro was studied. AA was evaluated by binding peroxidase-labeled soy bean and peanut lectins in the enzymatic color reaction and the subsequent comparison of the results with the know method of staining HN with crystal violet. The criterion(More)
The effects of new taurine derivatives TAU-15 and TAU-60 with normal and branched alkyl chains, respectively, in a dose of 25 mg/kg on the primary immune response in rats were studied in rats. Intraperitoneal injections of test compounds for 24 days caused transient inhibition of immune reactions to thymus-dependent antigen, which was related to suppressed(More)
Glioblastoma multiforme is an invasive malignant glial brain tumor with a poor prognosis for patients. The primary reasons that lead to the development of treatment resistance are associated with tumor cells infiltrating the brain parenchyma and the specific properties of tumor stem cells. A crucial research area in medical science is the search for(More)
The effect of C-reactive protein on oxygen metabolism and lysosomal activity of the human blood neutrophils was found to depend on its ability to conform and to render both the pro- and anti-inflammatory results. The serum amyloid P exerted mostly a consistent anti-inflammatory effect.
The work presents analysis of changes of humoral protective factors in the starfish Asterias rubens in response to injection of human erythrocytes (HE). The total protein concentration and the titers of hemagglutinins and hemolysins in starfish coelomic fluid, as well as the time of human hemoglobin elimination from circulation were estimated for 6–144 h of(More)
This study addresses the potential of flow cytometry in analyzing the composition of circulating hemocyte populations in the ascidian Halocynthia aurantium (Pallas, 1787), both using monoclonal antibodies (mAbs) against some conservative human leukocyte adhesion molecules and without mAbs. Flow cytometry, based on the assessment of forward and side light(More)
Synthesis of acute phase transmitters, migration and degranulation of pseudoeosinophils in hepatocytes, and damage to hepatocytes are observed during, the first few weeks of atherogenic diet. It is hypothesized that the acute phase reaction determines disturbances in the synthesis and catabolism of lipoproteins in the liver.
The aim of the present work was to develop a method for the simultaneous detection of mast cells (MC) and nerve fiber terminals based on methods developed for the histochemical identification of MC with Alcian blue and an immunochemical reaction for synaptophysin. The protocol developed here provides highly selective and reproducible simultaneous detection(More)